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Amide conjugates of the DO3A-N-(alfa-amino)propionate ligand : leads for stable...

A novel synthetic methodology for preparing amide conjugates of the DO3A-N-(alfa-amino)propionate chelator is described, using the synthesis of the DO3A-N-(alfa-benzoylamido)propionate chelator as an illustrative example. The model Gd(DO3A-N-(alfa-benzoylamido)propionate) chelate displays accelerated water exchange, stability in a wide pH range and inertness towards transmetallation by Zn2+. The Gd(DO3A-N-(al...

Synthesis of 2,6-bis-(oxazolyl)pyridine ligands for luminescent Ln(III) complexes

Submitted to the European Journal of Organic Chemistry ; New bis-(oxazolyl)pyridine ligands for Ln(III) ions were prepared using a expeditious methodology from threonine and dipicolinic acid chloride. The synthetic strategy includes a dehydration step to give a bis-dehydroaminobutyric acid derivative followed by bromination and cyclization with DBU. Photophysical studies of Eu(III) and Tb(III) complexes of th...

Gold nanoparticles functionalised with stable, fast water exchanging Gd3+ chela...

Gold nanoparticles functionalized with Gd3+ chelates displaying fast water exchange, superb pH stability and inertness towards transmetalation with Zn2+ have been prepared and characterized as a new high relaxivity (29 mM-1s-1, 30 MHz, 25 ºC) Contrast Agent potentially safe for in vivo MRI applications. The Lipari-Szabo treatment for internal rotation was used to evaluate the effect of linker flexibility on the...

Synthesis of a new 2,6-bis-(oxazole)pyridine ligand as a sensitizer for lumines...

Paramagnetic gold nanoparticles for MRI and therapeutic applications

Dissertação de mestrado em Química Medicinal ; A síntese de agentes quelantes bifuncionais do tipo poli(azacarboxilatos) contendo grupos pendentes para acoplamento a (bio)moléculas suscita um grande interesse na comunidade científica, pelas aplicações potenciais dos respectivos quelatos em imagiologia médica e para aplicações terapêuticas. O objectivo deste trabalho foi o desenvolvimento de vias sintéticas par...