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Positive Epistasis Drives the Acquisition of Multidrug Resistance
Trindade, S.; Sousa, A.; Xavier, KB.; Dionisio, F.; Ferreira, MG.; Gordo, I.The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact-epistasis. Information on the level of epistasis between antibiotic resistance mutations is of key importance to understanding epistasis amongst deleterious alleles, a...
Positive Epistasis Drives the Acquisition of Multidrug Resistance
Trindade, S.; Sousa, A.; Xavier, KB.; Dionisio, F.; Ferreira, MG.; Gordo, I.The evolution of multiple antibiotic resistance is an increasing global problem. Resistance mutations are known to impair fitness, and the evolution of resistance to multiple drugs depends both on their costs individually and on how they interact-epistasis. Information on the level of epistasis between antibiotic resistance mutations is of key importance to understanding epistasis amongst deleterious alleles, a...
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