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Ln[DO3A-N-α-(pyrenebutanamido)propionate] complexes: optimized relaxivity and N...
Ferreira, M. F.; Pereira, G.; Martins, A. F.; Martins, C. I. O.; Prata, M. I. M.; Petoud, S.; Toth, E.; Ferreira, P. M. T.; Martins, J. A.We have proposed recently that the DO3A-N-α-(amino)propionate chelator and its amide conjugates are leads to targeted, high relaxivity, safe contrast agents for magnetic resonance imaging. In this work we illustrate further the expeditious nature and robustness of the synthetic methodologies developed by preparing the DO3A-N-(α-pyrenebutanamido)propionate chelator. Its Gd3+ chelate retains the optimized water e...
New dextrin nanomagnetogels as contrast agents for magnetic resonance imaging
Gonçalves, C.; Lalatonne, Y.; Melro, L.; Badino, G.; Ferreira, M. F. M.; David, L.; Geraldes, C. F. G. C.; Motte, L.; Martins, J. A.; Gama, F. M.This study aims at the production and characterization of a “nanomagnetogel” consisting of superparamagnetic iron oxide nanoparticles (g-Fe2O3) stabilized within a hydrophobized-dextrin nanogel. The nanomagnetogel obtained was extensively characterized with respect to physico-chemical (transmission electron microscopy, cryo-scanning electron microscopy, dynamic light scattering, small angle X-ray scattering), m...
New dextrin nanomagnetogels as contrast agents for magnetic resonance imaging
Gonçalves, Catarina; Lalatone, Y.; Melro, Liliana Sofia da Silva Ferreira Pinto; Badino, G.; Ferreira, M. F. M.; David, L.; Geraldes, C. F. G. C.This study aims at the production and characterization of a “nanomagnetogel” consisting of superparamagnetic iron oxide nanoparticles (γ-Fe2O3) stabilized within a hydrophobized-dextrin nanogel. The nanomagnetogel obtained was extensively characterized with respect to physico-chemical (transmission electron microscopy, cryo-scanning electron microscopy, dynamic light scattering, small angle X-ray scattering), m...
Studies on the biodistribution of dextrin nanoparticles
Gonçalves, Clarisse; Ferreira, M. F. M.; Santos, A. C.; Prata, M. I. M.; Martins, J. A.; Geraldes, Carlos F. G. C.; Gama, F. M.The characterization of biodistribution is a central requirement in the development of biomedical applications based on the use of nanoparticles, in particular for controlled drug delivery. The blood circulation time, organ biodistribution and rate of excretion must be well characterized in the process of product development. In this work, the biodistribution of recently developed self-assembled dextrin nanopar...
Impact of the reactor bottom shape on the solid sodium borohydride hydrolysis f...
Ferreira, M. F. R.; Fernandes, Vitor R.; Rangel, C. M.; Pinto, A. M. F. R.Sodium borohydride (NaBH4) is a chemical hydride that produces hydrogen (H2) ‘on-demand’ through the reaction with water, and exhibits high gravimetric hydrogen storage capacity (10.8 wt.%). NaBH4 has been appointed as an efficient energy/hydrogen carrier for use with fuel cells [1-6]. Unfortunately, problems also exist with NaBH4 hydrolysis: H2 production rates are not sufficiently fast, reaction completion is...
The influence of building materials on the residual action of BHC
Penna,R.; Oliveira,A. E. X.; Ferreira,M. F. N.; Johnson,C.; Bosworth,A.; Marsden,P.Residual insecticide activity of BHC vapors from various building materials in controlled humidity chambers in the laboratory were significantly different. Laboratory-reared, first instar nymphs of Dipetalogaster maximus were exposed to vapors of BHC which were being released from the treated surfaces of building materials taken from Mambaí, Goiás.
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