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FASL polymorphism is associated with response to bacillus Calmette-Guérin immun...

Objective Deregulation of FAS/FASL system may lead to immune escape and influence bacillus Calmette-Guérin (BCG) immunotherapy outcome, which is currently the gold standard adjuvant treatment for high-risk non–muscle invasive bladder tumors. Among other events, functional promoter polymorphisms of FAS and FASL genes may alter their transcriptional activity. Therefore, we aim to evaluate the role of FAS and FASL...

Response of high-risk of recurrence/progression bladder tumours expressing sial...

High risk of recurrence/progression bladder tumours is treated with Bacillus Calmette-Guérin (BCG) immunotherapy after complete resection of the tumour. Approximately 75% of these tumours express the uncommon carbohydrate antigen sialyl-Tn (Tn), a surrogate biomarker of tumour aggressiveness. Such changes in the glycosylation of cell-surface proteins influence tumour microenvironment and immune responses that m...

The predominance of M2-polarized macrophages in the stroma of low-hypoxic bladd...

OBJECTIVE: Bacillus Calmette-Guérin (BCG) immunotherapy is the gold standard treatment for superficial bladder tumors with intermediate/high risk of recurrence or progression. However, approximately 30% of patients fail to respond to the treatment. Effective BCG therapy needs precise activation of the type 1 helper cells immune pathway. Tumor-associated macrophages (TAMs) often assume an immunoregulatory M2 phe...

Overexpression of tumour-associated carbohydrate antigen sialyl-Tn in advanced ...

Little is known on the expression of the tumour-associated carbohydrate antigen sialyl-Tn (STn), in bladder cancer. We report here that 75% of the high-grade bladder tumours, presenting elevated proliferation rates and high risk of recurrence/progression expressed STn. However, it was mainly found in non-proliferative areas of the tumour, namely in cells invading the basal and muscle layers. STn was also found ...

Gestão integrada de Portfólios IT

Tese de mestrado integrado. Engenharia Informátca e Computação. Faculdade de Engenharia. Universidade do Porto. 2008

Monitoring morphisms to support sustainable interoperability of enterprise systems

Dissertation to obtain the Master degree in Electrical Engineering and Computer Science ; Nowadays, organizations are required to be part of a global collaborative world. Sometimes this is the only way they can access new and wider markets, reaching new opportunities, skills and sharing assets, e.g. tools, lessons learnt. However, due to the different sources of enterprise models and semantics, organizations a...

Structural characterization of Helicobacter Pylori cell-surface lipopolysacchar...

Doutoramento em Bioquímica

Identification of cell-surface mannans in a virulent Helicobacter pylori strain

With the intent of contributing to a carbohydrate-based vaccine against the gastroduodenal pathogen, Helicobacter pylori, we report here the structure of cell-surface mannans obtained from a virulent strain. Unlike other wild-type strains, this strain was found to express in good quantities this polysaccharide in vitro. Structural analysis revealed a branched mannan formed by a backbone of α-(1→6)-linked mannop...

Process for detection of Helicobacter pylori using aliphatic amides

Evidences of exopolysaccharide production by Helicobacter pylori submitted to h...

Helicobacter pylori is a widespread Gram-negative bacterium that infects the stomach of humans leading to the onset of several gastric disorders, such as gastritis, gastric ulcers, and cancers. The transmission of H. pylori remains unclear but two different pathways have been suggested: faecal-oral and oraloral. It has been reported that H. pylori has the ability to incorporate in biofilms formed on water-expos...