Encontrados 4 documentos, a visualizar página 1 de 1
Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors
Mota, Sandra I.; Ferreira, Ildete L.; Rego, A. CristinaAlzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take several years to develop. Oligomeric amyloid-beta peptide (Aβ) plays a complex role in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in this devastating disease. Moreover, N-methyl-d-aspartate (NMDA) recept...
Dysfunctional synapse in Alzheimer’s disease – a focus on NMDA receptors
Mota, Sandra I.; Ferreira, Ildete L.; Rego, A. CristinaAlzheimer's disease (AD) is the most prevalent form of dementia in the elderly. Alterations capable of causing brain circuitry dysfunctions in AD may take several years to develop. Oligomeric amyloid-beta peptide (Aβ) plays a complex role in the molecular events that lead to progressive loss of function and eventually to neurodegeneration in this devastating disease. Moreover, N-methyl-d-aspartate (NMDA) recept...
Consequences of mitochondrial dysfunction in Huntington's Disease and protectio...
Cunha-Oliveira, Teresa; Ferreira, Ildete L; Rego, A CristinaHuntington’s Disease (HD) is an autosomal dominant neurodegenerative disorder clinically characterized by psychiatric disturbances, progressive cognitive impairment and choreiform movements. These symptoms are associated with the selective atrophy and neuronal loss in the striatum, cortex and hypothalamus. The disease is caused by a mutation at the 5’ terminal of the huntingtin (HTT) gene involving the expansio...
Glutamate in Life and Death of Retinal Amacrine Cells*
Duarte, Carlos B.; Ferreira, Ildete L.; Santos, Paulo F.; Carvalho, Ana L.; Agostinho, Paula M.; Carvalho, Arsélio P.1. Glutamate is the neurotransmitter released by bipolar cells at their synapses with amacrine cells. The amacrine cells express ionotropic (NMDA, AMPA and kainate) and metabotropic (mGluR1, mGluR2, mGluR4 and mGluR7) glutamate receptors and may take up glutamate from the synaptic cleft. ; http://www.sciencedirect.com/science/article/B6T71-3WDCGNH-6/1/585429baef39660288a51842ff1b4c33
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||