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Análise económica do rituximab, em associação com ciclofosfamida, vincristina e...

OBJECTIVE: Evaluate costs and benefits of rituximab in combination with cyclophosphamide/vincristine/prednisolone chemotherapy regimen (R-CVP), in previously untreated patients with indolent non-Hodgkin lymphoma (NHL), compared to CVP alone from a Portuguese National Health System (NHS) perspective. METHODS: Cost-effectiveness (Life Years Gained--LYG) and cost-utility analysis (Quality Adjusted Life Years--QALY...

Spatial pattern recognition of extreme temperature climatology: assessing HadCM...

This article attempts to quantify the spatial uncertainties associated with extreme temperature’s response, by assessing data derived from climate model. This is undertaken by a comparison of the spatial pattern of a long-term time-series aggregation (1960/61-1989/90) for extreme temperatures simulated by a particular GCM (the UK Met Office - Hadley Centre climate model, HadCM3) to that of the USA NCAR NCEP Rea...

Influences of cosmic radiation, artificial radioactivity and aerosol concentrat...

The atmospheric electric field is influenced by cosmic radiation, radioactivity and aerosols. In this work we investigate the existence of: (i) correlations between relative anomalies of annual values of atmospheric electric field and cosmic radiation intensity, artificial radioactivity and aerosol concentration; (ii) seasonal correlations between relative anomalies of the atmospheric electric field and cosmic ...

Synthesis and biological evaluation of new salicylate macrolactones from anacar...

In connection with our ongoing investigation in the search for new bioactive compounds using non-isoprenoid phenolic lipids from Anacardium occidentale as starting material, we describe the synthesis and cytotoxicity screening of some novel salicylate macrolactones prepared from anacardic acids, the major constitutents of natural cashew nut-shell liquid (CNSL).

The importance of fossil taxa in the knowledge of Neopterygian interrelationships

Caracterização de séries climatológicas pontuais via análise canônica de corres...

A possibilidade do clima de Belo Horizonte estar sendo afetado pelo comportamento do Oceano Pacífico tropical motivou a investigação que deu origem a este trabalho. Por este motivo, apresentamos análises estatísticas, não apenas do comportamento pontual médio mensal das variáveis atmosféricas em Belo Horizonte - MG (Brasil), como também da temperatura da superfície do mar nas regiões do Pacífico tropical, para ...