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Higher efficiency of the liver phosphorylative system in diabetic Goto-Kakizaki...
Palmeira, Carlos M.; Ferreira, F. M. L.; Santos, D. L.; Ceiça, R.; Suzuki, Ken-ichi; Santos, M. S.Liver mitochondrial bioenergetics of Goto-Kakizaki (GK) rats (a model of non-insulin dependent diabetes mellitus) reveals a [Delta][Psi] upon energization with succinate significantly increased relatively to control animals. The repolarization rate following ADP phosphorylation is also significantly increased in GK mitochondria in parallel with increased ATPase activity. The increase in the repolarization rate ...
Alterations of liver mitochondrial bioenergetics in diabetic Goto-Kakizaki rats
Ferreira, F. M. L.; Palmeira, C. M.; Seiça, R.; Santos, M. S.Respiratory indexes and the transmembrane electrical potential ([Delta][Psi]) were evaluated in mitochondrial preparations from 6-month-old Goto-Kakizaki (GK) and Wistar rats in the presence of glutamate + malate and succinate. We found that in diabetic GK mitochondria, flavin adenine dinucleotide (FAD)-linked respiratory indexes (respiratory control ratio [RCR] and adenosine diphosphate [ADP] to oxygen ratio [...
Decreased susceptibility to lipid peroxidation of Goto-Kakizaki rats: Relations...
Ferreira, F. M. L.; Palmeira, C. M.; Matos, M. J.; Seiça, R.; Santos, M. S.The respiratory function and the antioxidant capacity of liver mitochondrial preparations isolated from Goto-Kakizaki non-insulin dependent diabetic rats and from Wistar control rats, with the age of 6 months, were compared. It was found that Goto-Kakizaki mitochondrial preparations presented a higher coupling between oxidative and phosphorylative systems, compared to non-diabetic preparations. Goto-Kakizaki mi...
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