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Rapid test for the evaluation of the activity of the prodrug hydroxymethylnitro...
Barbosa,C.F.; Okuda,E.S.; Chung,M.C.; Ferreira,E.I.; Cicarelli,R.M.B.No fully effective treatment has been developed since the discovery of Chagas' disease by Carlos Chagas in 1909. Since drug-resistant Trypanosoma cruzi strains are occurring and the current therapy is effectiveness in the acute phase but with various adverse side effects, more studies are needed to characterize the susceptibility of T. cruzi to new drugs. Many natural and/or synthetic substances showing trypano...
Synthesis and characterization of membranes obtained by graft copolymerization ...
Santos, K. S. C. R. dos; Coelho, J. F. J.; Ferreira, P.; Pinto, I.; Lorenzetti, S. G.; Ferreira, E. I.; Higa, O. Z.; Gil, M. H.Chitosan based membranes to be applied on wound healing as topical drug delivery systems were developed by graft copolymerization of acrylic acid (AA) and 2-hydroxyethyl methacrylate (HEMA) onto chitosan using cerium ammonium nitrate as chemical initiator. Evidence for graft copolymerization of the vinyl monomers onto chitosan was obtained by FTIR and DMTA. Swelling degree, cytotoxicity, thrombogenicity and hae...
Thermal Characterization of Chitosan-Grafted Membranes to be Used as Wound Dres...
Ferreira, P.; Coelho, J. F. J.; Santos, K. S. C. R. dos; Ferreira, E. I.; Gil, M. H.Six different membranes previously prepared by the authors by graft copolymerization of acrylic acid (AA) and 2-hydroxyethylmethacrylate (HEMA) onto chitosan were characterized. The graft copolymerization of the vinyl monomers onto chitosan was confirmed by FTIR and DMTA. The chitosan used was also characterized by DMTA, which allowed addressing some questions related to the typical thermal transitions of this ...
Voltammetric behavior of benznidazole at a DNA-electrochemical biosensor
La-Scalea, M. A.; Serrano, S. H. P.; Ferreira, E. I.; Brett, A. M. OliveiraBenznidazole is a drug used commonly as a therapeutic agent against Chagas' disease in Brazil. To clarify the cytotoxic action of benznidazole the electrochemical reduction of benznidazole has been investigated using a DNA-electrochemical biosensor, prepared by modification of a glassy carbon electrode with DNA, and the results compared with reduction at a bare glassy carbon electrode. The dependence of peak po...
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