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Cyclodextrin multicomponent complexation and controlled release delivery strate...
Ribeiro, Laura S. S.; Falcão, Amílcar C.; Patrício, João A. B.; Ferreira, Domingos C.; Veiga, Francisco J. B.In the present work, to maintain a suitable blood level of vinpocetine (VP) for a long period of time, VP-cyclodextrin-tartaric acid multicomponent complexes were prepared and formulated in hydroxypropylmethylcellulose matrix tablets. In vitro and in vivo performances of these formulations were investigated over a VP immediate release dosage form. Solubility studies were performed to evaluate the drug pH solubi...
Cyclodextrin multicomponent complexation and controlled release delivery strate...
Ribeiro, Laura S. S.; Falcão, Amílcar; Patrício, João A. B.; Ferreira, Domingos C.; Veiga, Francisco J. B.In the present work, to maintain a suitable blood level of vinpocetine (VP) for a long period of time, VP-cyclodextrin-tartaric acid multicomponent complexes were prepared and formulated in hydroxypropylmethylcellulose matrix tablets. In vitro and in vivo performances of these formulations were investigated over a VP immediate release dosage form. Solubility studies were performed to evaluate the drug pH solubi...
Multicomponent complex formation between vinpocetine, cyclodextrins, tartaric a...
Ribeiro, Laura; Carvalho, Rui A.; Ferreira, Domingos C.; Veiga, Francisco J. B.This work deals with multicomponent complex formation of vinpocetine (VP) with [beta]-cyclodextrin ([beta]CD), sulfobutyl ether [beta]-cyclodextrin (SBE[beta]CD) and tartaric acid (TA), in the presence or absence of water-soluble polymers, in aqueous solution. Complexation was monitored by phase-solubility and proton nuclear magnetic resonance (1H NMR) studies. TA demonstrated a synergistic effect on VP solubil...
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