Encontrados 14 documentos, a visualizar página 1 de 2
Effect of adopting accounting standardization system NCRF 6 “Intangible Assets”
Helena Maria dos Santos Ferreira; Domingos José da Silva Cravo; Graça Maria do Carmo AzevedoThis study aims to analyse the effect of applyingNCFR 6 – Intangible Assets (NCRF 6) at the time ofthe transition from Portuguese local GAAP (POC) toAccounting Standardization System (SNC), focusing the analysis on the effects on the value of intangible assets, on the financial position, on the performance and on the economic and financial indicators.To accomplish that aim we performed...
Cyclodextrin multicomponent complexation and controlled release delivery strate...
Ribeiro, Laura S. S.; Falcão, Amílcar C.; Patrício, João A. B.; Ferreira, Domingos C.; Veiga, Francisco J. B.In the present work, to maintain a suitable blood level of vinpocetine (VP) for a long period of time, VP-cyclodextrin-tartaric acid multicomponent complexes were prepared and formulated in hydroxypropylmethylcellulose matrix tablets. In vitro and in vivo performances of these formulations were investigated over a VP immediate release dosage form. Solubility studies were performed to evaluate the drug pH solubi...
Oral Bioavailability of Insulin Contained in Polysaccharide Nanoparticles
Sarmento, Bruno; Ribeiro, António; Veiga, Francisco; Ferreira, Domingos; Neufeld, RonaldThe pharmacological activity of insulin-loaded dextran sulfate/chitosan nanoparticles was evaluated following oral dosage in diabetic rats. Nanoparticles were mucoadhesive and negatively charged with a mean size of 500 nm, suitable for uptake within the gastrointestinal tract. Insulin association efficiency was over 70% and was released in a pH-dependent manner under simulated gastrointestinal conditions. Orall...
Cyclodextrin multicomponent complexation and controlled release delivery strate...
Ribeiro, Laura S. S.; Falcão, Amílcar; Patrício, João A. B.; Ferreira, Domingos C.; Veiga, Francisco J. B.In the present work, to maintain a suitable blood level of vinpocetine (VP) for a long period of time, VP-cyclodextrin-tartaric acid multicomponent complexes were prepared and formulated in hydroxypropylmethylcellulose matrix tablets. In vitro and in vivo performances of these formulations were investigated over a VP immediate release dosage form. Solubility studies were performed to evaluate the drug pH solubi...
Insulin encapsulation in reinforced alginate microspheres prepared by internal ...
Silva, Catarina M.; Ribeiro, António J.; Ferreira, Domingos; Veiga, FranciscoInsulin-loaded alginate microspheres prepared by emulsification/internal gelation were reinforced by blending with polyanionic additive polymers and/or chitosan-coating in order to increase the protection of insulin at simulated gastric pH and obtain a sustained release at simulated intestinal pH. Polyanionic additive polymers blended with alginate were cellulose acetate phtalate (CAP), Eudragit® L100 (EL100), ...
Development and characterization of new insulin containing polysaccharide nanop...
Sarmento, Bruno; Ribeiro, António; Veiga, Francisco; Ferreira, DomingosA nanoparticle insulin delivery system was prepared by complexation of dextran sulfate and chitosan in aqueous solution. Parameters of the formulation such as the final mass of polysaccharides, the mass ratio of the two polysaccharides, pH of polysaccharides solution, and insulin theorical loading were identified as the modulating factors of nanoparticle physical properties. Particles with a mean diameter of 50...
Characterization of insulin-loaded alginate nanoparticles produced by ionotropi...
Sarmento, Bruno; Ferreira, Domingos; Veiga, Francisco; Ribeiro, AntónioInsulin-loaded nanoparticles were prepared by ionotropic pre-gelation of alginate with calcium chloride followed by complexation between alginate and chitosan. The influence of the pH and stoichiometry relationship between polyelectrolytes providing individual particles with a nano-scale size was assessed by photon correlation spectroscopy (PCS) and scanning electron microscopy (SEM). Insulin-polyelectrolyte in...
Development and validation of a rapid reversed-phase HPLC method for the determ...
Sarmento, Bruno; Ribeiro, António; Veiga, Francisco; Ferreira, DomingosA reversed-phase high-performance liquid chromatographic (HPLC) method has been developed and validated for the determination of insulin in nanoparticulate dosage forms. Its application for the development and characterization of insulin-loaded nanoparticulates composed of polyelectrolytes has also been carried out. A reversed-phase (RP) C18 column and gradient elution with a mobile phase composed of acetonitri...
Development and Comparison of Different Nanoparticulate Polyelectrolyte Complex...
Sarmento, Bruno; Martins, Susana; Ribeiro, António; Veiga, Francisco; Neufeld, Ronald; Ferreira, DomingosThe overall objective of our research is to produce polyanion/chitosan nanoparticulate oral delivery systems for insulin. Specific objectives of the present study were to study dextran sulfate or alginate complexation with chitosan on mean particle size, insulin association efficiency, loading capacity and release profile. Nanoparticles were formed by ionotropic complexation and coacervation between polyanions ...
Chitosan-reinforced alginate microspheres obtained through the emulsification/i...
Ribeiro, António J.; Silva, Catarina; Ferreira, Domingos; Veiga, FranciscoAlginate microspheres prepared by emulsification/internal gelation were chosen as carriers for a model protein, hemoglobin (Hb). Reinforced chitosan-coated microspheres were obtained by an uninterrupted method, in order to simplify the coating process, minimize protein losses during production and to avoid Hb escape under acidic conditions. Microspheres recovery was evaluated as well as its morphology by determ...
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