Encontrados 23 documentos, a visualizar página 1 de 3
A novel risk-based decision-making paradigm
Morgado, Pedro; Marques, Fernanda; Silva, Miguel; Sousa, Nuno; Cerqueira, Jo??oThis paper presents a novel rodent decision-making task that explores uncertainty, independently of expectation and predictability. Using a 5-hole operating box, adult male Wistar rats were given choices between a small certain (safe) food reward and a large uncertain (risk) food reward. We found that animals strongly preferred the safe option when it had a fixed position or was cued with a light in a random pl...
Lipocalin-2 is involved in emotional behaviors and cognitive function
Ferreira, Ana Catarina; Pinto, Vítor; Mesquita, Sandro; Novais, Ashley da Cruz; Sousa, João Carlos; Neves, Margarida Correia; Sousa, NunoLipocalin-2 is involved in emotional behaviors and cognitive function ; Lipocalin-2 (LCN2), an iron-related protein well described to participate in the innate immune response, has been shown to modulate spine morphology and to regulate neuronal excitability. In accordance, LCN2-null mice are reported to have stress-induced anxiety. Here we show that, under standard housing conditions, LCN2-null mice display a...
Stress impact on resting state brain networks
Soares, José Miguel; Sampaio, Adriana; Ferreira, Luís Miguel; Santos, Nadine Correia; Marques, Fernanda; Palha, Joana Almeida; Cerqueira, JoãoResting state brain networks (RSNs) are spatially distributed large-scale networks, evidenced by resting state functional magnetic resonance imaging (fMRI) studies. Importantly, RSNs are implicated in several relevant brain functions and present abnormal functional patterns in many neuropsychiatric disorders, for which stress exposure is an established risk factor. Yet, so far, little is known about the effect ...
Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons...
João, Bessa; Morais, Mónica; Marques, Fernanda; Pinto, Luísa; Palha, Joana Almeida; Sousa, NunoThere is accumulating evidence that the nucleus accumbens (NAc) has an important role in the pathophysiology of depression. As the NAc is a key component in the neural circuitry of reward, it has been hypothesized that anhedonia, a core symptom of depression, might be related to dysfunction of this brain region. Neuronal morphology and expression of plasticity-related molecules were examined in the NAc of rats ...
Plasticity of resting state brain networks in recovery from stress
Marques, Fernanda; Palha, Joana Almeida; Cerqueira, Jo??o; Soares, Jos?? Miguel; Sousa, Nuno; Santos, Nadine Correia; Marques, Paulo C??sar Gon??alvesChronic stress has been widely reported to have deleterious impact in multiple biological systems. Specifically, structural and functional remodeling of several brain regions following prolonged stress exposure have been described; importantly, some of these changes are eventually reversible. Recently, we showed the impact of stress on resting state networks (RSNs), but nothing is known about the plasticity of ...
Blood-brain-barriers in aging and in Alzheimer's disease
Marques, Fernanda; Sousa, João Carlos; Sousa, Nuno; Palha, Joana AlmeidaThe aging process correlates with a progressive failure in the normal cellular and organ functioning; these alterations are aggravated in Alzheimer's disease (AD). In both aging and AD there is a general decrease in the capacity of the body to eliminate toxic compounds and, simultaneously, to supply the brain with relevant growth and nutritional factors. The barriers of the brain are targets of this age related...
Neudesin is involved in anxiety behavior : structural and neurochemical correlates
Novais, Ashley da Cruz; Ferreira, Ana C.; Marques, Fernanda; Pêgo, José M.; Cerqueira, João; Pereira, Ana Carla David; Campos, Filipa L.Neudesin (also known as neuron derived neurotrophic factor, Nenf) is a scarcely studied putative non-canonical neurotrophic factor. In order to understand its function in the brain, we performed an extensive behavioral characterization (motor, emotional, and cognitive dimensions) of neudesin-null mice. The absence of neudesin leads to an anxious-like behavior as assessed in the elevated plus maze (EPM), light/d...
Unbiased stereological method to assess proliferation throughout the subependym...
Palha, Joana Almeida; Oliveira, Ana Catarina; Marques, Fernanda; Sousa, Nuno; Sousa, João CarlosThe subependymal zone (SEZ), frequently named as adult subventricular zone (SVZ), is a niche of adult neural stem and progenitor cells that lines a large extension of the lateral ventricles of the brain. The majority of the studies do not analyze the SEZ throughout its entire extension. Instead, studies of cell populations within the SEZ typically focus their analysis on a narrow space between specific bregma c...
Topographical analysis of the subependymal zone neurogenic niche
Falcão, Ana M.; Palha, Joana Almeida; Ferreira, Ana Catarina; Marques, Fernanda Cristina Gomes de Sousa; Sousa, Nuno; Sousa, João CarlosThe emerging model for the adult subependymal zone (SEZ) cell population indicates that neuronal diversity is not generated from a uniform pool of stem cells but rather from diverse and spatially confined stem cell populations. Hence, when analysing SEZ proliferation, the topography along the anterior-posterior and dorsal-ventral axes must be taken into account. However, to date, no studies have assessed SEZ pr...
Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of...
Mesquita, Sandro; Ferreira, A. C.; Sousa, João Carlos; Santos, Nadine Correia; Neves, Margarida Correia; Sousa, Nuno; Palha, Joana AlmeidaIron is essential for mammalian cellular homeostasis. However, in excess, it promotes free radical formation and is associated with aging-related progressive deterioration and with neurodegenerative disorders such as Alzheimer's disease (AD). There are no mechanisms to excrete iron, which makes iron homeostasis a very tightly regulated process at the level of the intestinal absorption. Iron is believed to reach...
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