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Sitagliptin treatment prevented pancreatic lesions evolution in a rat modelo f ...

Background: This study aimed to elucidate mechanisms underlying the protective effects of sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, against pancreatic lesions, in an animal model of T2DM. Methods: Male obese diabetic ZDF (fa/fa) rats, 20-weeks-old, were treated with vehicle or sitagliptin (10mg/kg BW/day) for 6 weeks, and compared with lean control littermates (n=8/each). Biochemical parameters ...

Validation of a fluorescence in situ hybridization method using peptide nucleic...

Here, we evaluated a previously established peptide nucleic acid-fluorescence in situ hybridization (PNA-FISH) method as a new diagnostic test for Helicobacter pylori clarithromycin resistance detection in paraffin-embedded gastric biopsy specimens. Both a retrospective study and a prospective cohort study were conducted to evaluate the specificity and sensitivity of a PNA-FISH method to determine H. pylori cla...

Probe4pylori : a new kit for the rapid detection of H. pylori and associated cl...

In this study an evaluation of Probe4Pylori, a previously established PNA-FISH diagnostic test for H. pylori clarithromycin resistance in paraffin embedded gastric biopsies was performed and compared against culture followed by E-test and PCR. The Probe4Pylori showed very promising results with values of sensitivity (80%) and specificity (approximately 90%) for the patients harboring clarithromycin-resistant H....

Non-Transferrin-Bound Iron (NTBI) Uptake by T Lymphocytes: Evidence for the Sel...

Iron is an essential nutrient in several biological processes such as oxygen transport, DNA replication and erythropoiesis. Plasma iron normally circulates bound to transferrin. In iron overload disorders, however, iron concentrations exceed transferrin binding capacity and iron appears complexed with low molecular weight molecules, known as non-transferrin-bound iron (NTBI). NTBI is responsible for the toxicit...

C3G - A portuguese collaboratorium for Geology, Geodesy and Geophysics

Sitagliptin delays progression of renal lesions in a rodent model of type 2 dia...

Diabetic Mastopathy: a Case Report

Diabetic mastopathy (DMP) is an uncommon collection of clinical, radiological, and histological features, classically described in premenopausal women with long-term insulin-dependent diabetes mellitus. This entity can mimic breast carcinoma, but, in the appropriate clinical and imaging setting, the diagnosis can be made by core biopsy, avoiding unnecessary surgeries. We report the case of a 34-year-old female,...

Prognóstico Obstétrico de Pacientes Portadoras de Diabetes Mellitus Pré-Gestaci...

OBJETIVO: Avaliar as alterações epidemiológicas, de perfil clínico e de prognóstico obstétrico em pacientes portadoras de diabetes mellitus pré-gestacional. MÉTODOS: Estudo retrospetivo (coorte) de todas as gestações simples, com diagnóstico de diabetes prévio que foram seguidas num centro com apoio perinatal diferenciado entre 2004 e 2011 (n=194). Analisaram-se tendências relacionadas com dados demográficos e ...

Os Sistemas de Informação Geográfica como ferramenta de apoio à decisão em Prot...

Os Sistemas de Informação Geográfica como ferramenta de apoio à decisão em Proteção Civil.

Influence of land use on nutrients transport using SWAT model: Study case of Ar...

The impacts of agricultural activities in the environment are due to the lixiviation and soil erosion. Pollution of agricultural origin presents diffuse characteristics reaching the environment through surface runoff, lateral flow and groundwater flow. Models can contribute to understand the sources and the processes responsible for pollution, also identifying areas of concern. To evaluate the status of river w...