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Synthesis and studies of calcium channel blocking and antioxidant activities of...
Rucins, Martins; Kaldre, Dainis; Pajuste, Karlis; Fernandes, Maria A. S.; Vicente, Joaquim A. F.; Klimaviciusa, Linda; Jaschenko, ElinaThe novel 1,4-dihydropyridine derivatives containing the cationic pyridine moiety at the position 4, and the N-propargyl group as a substituent at position 1 of the 1,4-DHP cycle were designed, synthesised, and assessed in biological tests. Among all the novel compounds, the 4-(N-dodecyl) pyridinium group-containing compounds 11 (without the N-propargyl group) and 12 (with the N-propargyl group) demonstrated th...
Comparative effects of three 1,4-dihydropyridine derivatives [OSI-1210, OSI-121...
Fernandes, Maria A. S.; Pereira, Susana P. S.; Jurado, Amália S.; Custódio, José B. A.; Santos, Maria S.; Moreno, António J. M.; Duburs, GunarsThe 1,4-dihydropyridines OSI-1210, OSI-1211 (etaftoron), and OSI-3802 are compounds with similar chemical structure. They differ by the length of the alkoxyl chain in positions 3 and 5 of the dihydropyridine (DHP) ring and by their pharmacological action characteristics. However, as far as we know, a clear relationship between the effects of these compounds and the length of the alkoxyl chain in positions 3 and...
Mitochondria as the target for mildronate's protective effects in azidothymidin...
Pupure, Jolanta; Fernandes, Maria A. S.; Santos, Maria S.; Moreno, António J. M.; Kalvinsh, Ivars; Klusa, Vija; Oliveira, Catarina R.Previously mildronate, an aza-butyrobetaine derivative, was shown to be a cytoprotective drug, through its mechanism of action of inhibition of carnitine palmitoyltransferase-1, thus protecting mitochondria from long-chain fatty acid accumulation and subsequent damage. Recently in an azidothymidine (AZT)-induced cardiotoxicity model in vivo (in mice), we have found mildronate's ability of protecting heart tissu...
Tetrandrine concentrations not affecting oxidative phosphorylation protect rat ...
Fernandes, Maria A. S.; Custódio, José B. A.; Santos, Maria S.; Moreno, António J. M.; Vicente, Joaquim A. F.The effects of tetrandrine (6,6', 7,12-tetramethoxy-2, 2'-dimethyl-berbaman) on the mitochondrial function were assessed on oxidative stress, mitochondrial permeability transition (MPT), and bioenergetics of rat liver mitochondria. At concentrations lower than 100 nmol/mg protein, tetrandrine decreased the hydrogen peroxide formation, the extent of lipid peroxidation, the susceptibility to Ca2+-induced opening ...
Glibenclamide interferes with mitochondrial bioenergetics by inducing changes o...
Fernandes, Maria A. S.; Santos, Maria S.; Moreno, António J. M.; Duburs, Gunars; Oliveira, Catarina R.; Vicente, Joaquim A. F.The interference of glibenclamide, an antidiabetic sulfonylurea, with mitochondrial bioenergetics was assessed on mitochondrial ion fluxes (H+, K+, and Cl-) by passive osmotic swelling of rat liver mitochondria in K-acetate, KNO3, and KCl media, by O2 consumption, and by mitochondrial transmembrane potential (Deltapsi). Glibenclamide did not permeabilize the inner mitochondrial membrane to H+, but induced perme...
Effects of 1,4-dihydropyridine derivatives (cerebrocrast, gammapyrone, glutapyr...
Fernandes, Maria A. S.; Santos, Maria S.; Vicente, Joaquim A. F.; Moreno, António J. M.; Velena, Astrida; Duburs, Gunars; Oliveira, Catarina R.The potential protective action of 1,4-dihydropyridine derivatives (cerebrocrast, gammapyrone, glutapyrone, and diethone) against oxidative stress was assessed on mitochondrial bioenergetics, inner membrane anion channel (IMAC), Ca2+-induced opening of the permeability transition pore (PTP), and oxidative damage induced by the oxidant pair adenosine diphosphate (ADP)/Fe2+ (lipid peroxidation) of mitochondria is...
Effects of NADH and H2O2 on Chromate-Induced Human Erythrocytes Hemoglobin Oxid...
Fernandes, Maria A. S.; Geraldes, Carlos F. G. C.; Oliveira, Catarina R.; Alpoim, Maria C.The effects of NADH and H2O2 on chromate-induced human erythrocyte hemoglobin oxidation and peroxidation were studied. It was observed that NADH decreases the levels of chromate-induced human erythrocyte hemoglobin oxidation and peroxidation. H2O2 decreases the levels of chromate-induced hemoglobin oxidation, but increases the levels of chromate-induced peroxidation. The ability of H2O2 to decrease the levels o...
Chromate-induced human erythrocytes haemoglobin oxidation and peroxidation: inf...
Fernandes, Maria A. S.; Geraldes, Carlos F. G. C.; Oliveira, Catarina R.; Alpoim, Maria C.In order to attenuate or to prevent chromate-induced human erythrocytes injury, the influence of vitamin E, vitamin C, salicylate, deferoxamine, and N-ethylmaleimide on chromate-induced human erythrocytes haemoglobin oxidation and peroxidation were investigated. It was observed that pretreatment of human erythrocytes with vitamin E (20 [mu]M), vitamin C (1 mM), salicylate (3 mM), and deferoxamine (4 mM) signifi...
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