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Qualidade de vida e maus-tratos do idoso na comunidade

O presente estudo acerca dos maus-tratos e qualidade de vida no idoso tem como objectivos avaliar a influência do risco do abuso ou negligência na qualidade de vida dos idosos; avaliar o risco de abuso e/ou negligência e avaliar a qualidade de vida dos idosos no contexto comunitário. Optou-se pela investigação quantitativa do tipo descritiva-exploratória, de natureza transversal, a 48 indivíduos de ambos os gén...

Electrochemical characterization of bioactive hydroxyxanthones by cyclic voltam...

The present study reports the electrochemical behavior of several phenolic and catecholic-substituted 2,3-diarylxanthones on a glassy carbon electrode, challenged by cyclic voltammetry at different pH values (4.0, 7.4, and 11.0). Higher pH values required lower anodic and cathodic peak voltages. The oxidation of catecholic groups occurred at lower peak potentials in a reversible and pH dependent manner. Anodic ...

Electrochemical behavior of Hydroxyxanthones versus ROS scavenging activities

Xanthones are a class of naturally-occurring oxygenated heterocyclic compounds with a broad spectrum of biological activities of great interest for potential therapeutic applications. 1 IJ Thus, over the last decades a great number of publications have emerged focusing on the isolation and s~nthesis of these natural compounds or even in the search for novel bioactive derivatives.1- 1 Electrochemical methodologi...

The dependence of alpha-tocopheroxyl radical reduction by hydroxy-2,3-diarylxan...

The flavonoid quercetin is known to reduce the α-tocopheroxyl radical (˙TocO) and reconstitute α-tocopherol (TocOH). Structurally related polyphenolic compounds, hydroxy-2,3-diarylxanthones (XH), exhibit antioxidant activity which exceeds that of quercetin in biological systems. In the present study repair of ˙TocO by a series of these XH has been evaluated using pulse radiolysis. It has been shown that, among ...

Electrochemical characterization of hydroxylated xanthones by cyclic voltammetry

Xanthones constitute a class of oxygenated heterocyclic compounds commonly identified in some higher plant families, fungi and lichens [1]. Their large variety of biological and pharmacological activities encouraged the scientific community for the search and isolation of natural derivatives for therapeutic applications [2]. Consequently, extensive studies have been devoted to the development of synthetic route...

2,3-Diarylxanthones as strong scavengers of reactive oxygen and nitrogen specie...

Xanthones are a class of oxygen-containing heterocyclic compounds widely distributed in nature. The natural derivatives can present different substitutions in the xanthone core that include hydroxyl, methoxyl, prenyl and glycosyl groups. The inclusion of aryl groups has only been reported for a few synthetic derivatives, the 2,3-diaryl moiety being recently introduced by our group. Xanthones are endowed with a ...

Metodologias para avaliar a actividade captadora de espécies reactivas de oxigé...

As espécies reactivas de oxigénio (ERO) e de azoto (ERA) estão envolvidas nos processos inflamatórios, nomeadamente através da sua produção c libertação pelos neutrófilos. Apesar da produção dessas espécies fazer pal1e dos mecanismos de defesa inata do organismo, por vezes esta torna-se descontrolada, com efeitos deletérios para os tecidos. Na verdade, foi já sugerido em diferentes estudos que a actividade anti...

NDPO2 as a selective generator of 1o2 used in the scavenging activity assay of ...

The 2-styrylchromone structure is an effective scaffold for the development of ...

ROS and RNS Scavenging Activity by 2,3-Diarylxanthones

Xanthones constitute an important class of heterocyclic compounds that commonly occur in nature. The inclusion of aryl groups has only been reported for a few synthetic derivatives, being the 2,3-diaryl moiety recently introduced by our group.~ The pharmacological properties of both natural and synthetic xanthones have attracted great attention namely as antioxidant, anti-allergic, anti-inflammatory, antimalari...