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The selective COX-2 inhibitor etoricoxib reduces acute inflammatory markers in ...

Rodrigues, Manuel Lima; Lamas, Nuno Jorge; Fernandes, Ana Valle; Cruz, Andrea; Vieira, Artur Jorge Gomes; Oliveira, Pedro; Pedrosa, Jorge

The selective COX-2 inhibitor Etoricoxib reduces acute inflammatory markers in a model of neurogenic laryngitis but loses its efficacy with prolonged treatment. ; OBJECTIVE: A randomised experimental study was used to evaluate the therapeutic effect of a selective cyclooxygenase-2 (COX-2) inhibitor in neurogenic laryngitis. MATERIALS AND METHODS: Male Wistar Han rats were subjected to the nasogastric intubatio...


A new model of laryngitis : neuropeptide, cyclooxygenase, and cytokine profile

Rodrigues, Manuel Lima; Fernandes, Ana Valle; Lamas, Nuno Jorge; Cruz, Andrea; Baltazar, Fátima; Milanezi, Fernanda; Nunes, Rui; Reis, R. M.


Distribution of neuromuscular junctions in laryngeal and syringeal muscles in v...

Rodrigues, Manuel Lima; Fernandes, Ana Valle; Nunes, Rui; Almeida, Armando

Vertebrates are capable of producing a variable sound spectrum. In mammals, lissamphibia, and reptiles, the larynx is the vocal organ responsible for sound production, whereas in birds it is produced by the syrinx, an avian organ located at the base of trachea. The distribution of neuromuscular junctions responsible for the fine control of laryngeal muscle (LM) and syringeal muscle (SM), although studied with s...


Brain projections from the medullary dorsal reticular nucleus : an anterograde ...

Almeida, Hugo Leite; Fernandes, Ana Valle; Almeida, Armando

In the last 15 years a role has been ascribed for the medullary dorsal reticular nucleus as a supraspinal pain modulating area. The medullary dorsal reticular nucleus is reciprocally connected with the spinal dorsal horn, is populated mainly by nociceptive neurons and regulates spinal nociceptive processing. Here we analyze the distribution of brain projections from the medullary dorsal reticular nucleus using ...


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Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia