A determinação do status da proteína HER2 por imunocitoquímica é uma metodologia fundamental para o diagnóstico, prognóstico e indicação terapêutica no carcinoma da mama, nomeadamente para o encaminhamento terapêutico com Herceptin®/trastuzumab. O estabelecimento desta terapêutica nas vertentes adjuvante ou neoadjuvante, e até em doença metastática, tem vindo a acentuar a importância da determinação do referido...
Tese de doutoramento em Engenharia de Materiais ; For the past decades, the technological and industrial development has resulted in high demanding of the society. This is many times translated in the need to have a material with intrinsic properties for a certain application, justifying the investments in the area of thin film technology. Due to the increasing demands of the technology applications, the conti...
The optical properties of TiC x O y thin films, deposited by reactive dc magnetron sputtering at different oxygen flow, were investigated by spectroscopic ellipsometry in the energy range of 0.75–4.5 eV. The dielectric functions measured in the energy range of intraband transitions were analyzed using the classical Drude theory. These results show that free plasma energy and the damping constant of the fil...
As a result of technological progress in recent years, a new challenge was passed onto decorative hard coatings. While enhancing the appearance and lending attractive coloration to surfaces, the films are supposed to provide scratch resistance, protection against corrosion and durability. For this work, TiN(O) and TiN(C,O) thin films were prepared. Within the TiN(O) system, film colours varied from the glossy g...
Prova Tipográfica (In Press) ; Recently, tribocorrosion is widely accepted as an interdisciplinary area of research and such studies on various materials are gaining more attention by scientists and engineers due to its practical and economical significances in a wide range of applications. The main objective of the present work were to investigate the tribocorrosion behaviour of single layered titanium oxycar...
Recently, tribocorrosion is widely accepted as an interdisciplinary area of research and such studies on the various materials is gaining more attention by the scientist and engineers due to its practical and economical significances. Hence the main objective of present work was to investigate the tribocorrosion behavior of single layered titanium oxycarbide, TiCxOy, thin films on a reciprocating sliding tribo-...
We have studied the structural, electronic and mechanical properties of TiCxOy, using first principles calculations based on the density functional theory and pseudopotential method, within the generalized gradient approximation for the exchange–correlation functional. These calculations provide the lattice parameter, density of states, cohesive energy, elastic constants and moduli as a function of carbon and o...
This paper reports the influence of low pressure plasma nitriding treatments, some of them followed by plasma assisted oxidation on the mechanical properties and tribocorrosion resistance of a Ti6Al4V alloy. Nitridation was performed for 640 or 720 min at 600 and 700 °C in a r.f. plasma equipment, using a N2–H2 gas mixture at 7.5 Pa. Some of the samples were then post-oxidized at 700 °C for 15 and 60 min, withi...
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