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Sustained oxidative stress inhibits NF-[kappa]B activation partially via inacti...
Wu, Mingxing; Bian, Qingning; Liu, Yizhi; Fernandes, Alexandre F.; Taylor, Allen; Pereira, Paulo; Shang, Fuhttp://www.sciencedirect.com/science/article/B6T38-4TK92CN-1/2/ef8f7b10021e625df74be4471bbf0552
Data: 2009
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Origem: Estudo Geral - Universidade de Coimbra
Proteasome-dependent regulation of signal transduction in retinal pigment epith...
Fernandes, Alexandre F.; Guo, Weimin; Zhang, Xinyu; Gallagher, Matthew; Ivan, Mircea; Taylor, Allen; Pereira, Paulo; Shang, FuAs in many other types of cells, retinal pigment epithelial (RPE) cells have an active ubiquitin-proteasome pathway (UPP). However, the function of the UPP in RPE remains to be elucidated. The objective of this study is to determine the role of the UPP in controlling the levels and activities of transcription factors hypoxia-inducible factor (HIF) and NF-[kappa]B. We inhibited the UPP with proteasome-specific i...
Data: 2006
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Origem: Estudo Geral - Universidade de Coimbra
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