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The human umbilical cord tissue-derived MSC population UCX® promotes early moto...

Miranda JP, JP; Filipe, E; Fernandes, AS; Almeida, JM; Martins, JP; De La Fuente, A; Abal, M; Barcia, RN; Cruz, P; Cruz, H; Castro, M; Santos, JM

Mesenchymal stromal cells (MSCs) play an important role in tissue regeneration mainly through the secretion of trophic factors that enhance the repair of damaged tissues. The main goal of this work was to study the paracrine mechanisms by which an umbilical cord tissue-derived MSC population (UCX®) promotes the migration capacity of human dermal fibroblasts and keratinocytes, which is highly relevant for skin r...


Mechanistic insights into the cytotoxicity and genotoxicity induced by glycidam...

Bandarra, S; Fernandes, AS; Magro, I; Guerreiro, PS; Pingarilho, M; Churchwell, MI; Gil, OM; Batinic-Haberle, I; Gonçalves, S; Rueff, J; Miranda, JP

Acrylamide (AA) is a well-known industrial chemical classified as a probable human carcinogen. Benign and malignant tumours at different sites, including the mammary gland, have been reported in rodents exposed to AA. This xenobiotic is also formed in many carbohydrate-rich foods prepared at high temperatures. For this reason, AA is an issue of concern in terms of human cancer risk. The epoxide glycidamide (GA)...



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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia