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Design of polymeric nanoparticles and its applications as drug delivery systems...
Reis, C. P.; Martinho, N.; Rosado, C.; Fernandes, A. S.; Roberto, A.Objective: The aim of this study was to evaluate a formulation made of poly(lactide-co-glycolide) (PLGA) nanoparticles containing azelaic acid for potential acne treatment. Methods: Azelaic acid-loaded PLGA nanoparticles were prepared by spontaneous emulsification processes using poloxamer 188 as stabilizer. Several manufacturing parameters such as stirring rate, concentration of stabilizer and different recov...
Antimicrobial plant extracts encapsulated into polymeric beads for potential ap...
Rijo, P.; Matias, D.; Fernandes, A. S.; Simões, M. F.; Nicolai, M.; Reis, C. P.In this study, the in vitro bacterial growth inhibition, antioxidant activity and the content in bioactive components of Plectranthus barbatus, P. hadiensis var. tomentosus, P. madagascarensis, P. neochilus and P. verticillatus aqueous extracts were investigated and compared by three extraction methods (infusion, decoction and microwave extractions). The microwave extract of P. madagascariensis showed the highe...
[15]aneN4S: synthesis, thermodynamic studies and potential applications in chel...
Torres, N.; Gonçalves, S.; Fernandes, A. S.; Machado, J. F.; de Brito, M. J.; Oliveira, N. G.; Castro, M.; Costa, J.; Cabral, M. F.The purpose of this work was to synthesize and characterize the thiatetraaza macrocycle 1-thia-4,7,10,13-tetraazacyclopentadecane ([15]aneN4S). Its acid-base behaviour was studied by potentiometry at 25 °C and ionic strength 0.10 M in KNO3. The protonation sequence of this ligand was investigated by 1H-NMR titration that also allowed the determination of protonation constants in D2O. Binding studies of [15]aneN...
Differential effects of methoxyamine on doxorubicin cytotoxicity and genotoxici...
Guerreiro, P. S.; Fernandes, A. S.; Costa, J. G.; Castro, M.; Miranda, J. P.; Oliveira, N. G.Pharmacological inhibition of DNA repair is a promising approach to increase the effectiveness of anticancer drugs. The chemotherapeutic drug doxorubicin (Dox) may act, in part, by causing oxidative DNA damage. The base excision repair (BER) pathway effects the repair of many DNA lesions induced by reactive oxygen species (ROS). Methoxyamine (MX) is an indirect inhibitor of apurinic/apyrimidinic endonuclease 1 ...
Synthesis and Biological Activity of 6-Selenocaffeine: Potential Modulator of C...
Martins, I. L.; Miranda, J. P.; Oliveira, N. G.; Fernandes, A. S.; Gonçalves, S.; Antunes, A. M.We report the development of a new microwave-based synthetic methodology mediated by Woollins’ reagent that allowed an efficient conversion of caffeine into 6-selenocaffeine. A preliminary evaluation on the modulation of antioxidant activity upon selenation of caffeine, using the DPPH assay, indicated a mild antioxidant activity for 6-selenocaffeine, contrasting with caffeine, that exhibited no antioxidant acti...
Development of pyridine-containing macrocyclic copper(II) complexes: potential ...
Fernandes, A. S.; Costa, J.; Gaspar, J.; Rueff, J.; Cabral, M. F.; Cipriano, M.; Castro, M.; Oliveira, N. G.The unique redox and catalytic chemistry of Cu has justified the development of novel Cu complexes for different therapeutic uses including cancer therapy. In this work, four pyridine-containing aza-macrocyclic copper(II) complexes were prepared (CuL1-CuL4) varying in ring size and/or substituents and their superoxide scavenging activity evaluated. CuL3, the most active superoxide scavenger, was further studied...
Cytotoxic effects of cadmium in mammary epithelial cells: Protective role of th...
Gonçalves, S; Fernandes, A. S.; Oliveira, N. G.; Marques, J.; Costa, J.; Cabral, M. F.; Miranda, J.; Cipriano, M.; Guerreiro, P. S.; Castro, M.Human exposure to cadmium (Cd) occurs via different routes, including diet. The increasing amount of data linking Cd with different cellular effects in the mammary gland justifies additional toxicological assessments using human mammary epithelial cells. This work aimed therefore to assess the cytotoxic effects of Cd in MCF10A cells and to characterize the cytoprotective role of the macrocycle [15]pyN5 in the f...
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