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Yeast chronological lifespan and proteotoxic stress : is autophagy good or bad
Sampaio-Marques, Belém; Felgueiras, Carolina; Silva, Alexandra; Rodrigues, Fernando José dos Santos; Ludovico, PaulaAutophagy, a highly conserved proteolytic mechanism of quality control, is essential for the maintenance of metabolic and cellular homoeostasis and for an efficient cellular response to stress. Autophagy declines with aging and is believed to contribute to different aspects of the aging phenotype. The nutrient-sensing pathways PKA (protein kinase A), Sch9 and TOR (target of rapamycin), involved in the regulation...
Data: 2011
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Origem: RepositóriUM - Universidade do Minho
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