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Molecular mobility, composition and structure analysis in glycerol plasticised ...
Fundo, J. F.; Fernandes, Rui; Almeida, Pedro M.; Carvalho, Alexandra; Feio, Gabriel; Silva, Cristina L. M.; Quintas, Mafalda A. C.This study was developed with the purpose to investigate the effect of polysaccharide/plasticiser concentration on the microstructure and molecular dynamics of polymeric film systems, using transmission electron microscope imaging (TEM) and nuclear magnetic resonance (NMR) techniques. Experiments were carried out in chitosan/glycerol films prepared with solutions of different composition. The films obtained aft...
Release profile of ibuprofen in β-cyclodextrin complexes from two different sol...
Salústio, Paulo; Feio, Gabriel; Figueirinhas, João; Cabral-Marques, Helena; Costa, Paulo; Pinto, JoãoThe objective of this work was to develop solid dosage forms using powders containing inclusion complexes (ibuprofen with β-cyclodextrin) which were used to produce tablets (direct compression without additional excipients) and pellets (extrusion/spheronization) from wet mass containing 40% (w/w) of microcrystalline cellulose. The pellets also demonstrated that during preparation of the wet mass, the inclusion ...
The influence of the preparation methods on the inclusion of model drugs in a β...
Salústio, Paulo; Feio, Gabriel; Figueirinhas, João; Pinto, João; Marques, Helena CabralNOTICE: this is the author’s version of a work that was accepted for publication in European Journal of Pharmaceutics and Biopharmaceutics. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A def...
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