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Extensional flow-based microfluidic device: deformability assessment of red blo...
Faustino, Vera; Pinho, Diana; Yaginuma, T.; Calhelha, Ricardo C.; Ferreira, Isabel C.F.R.; Lima, R.Red blood cell (RBC) deformability has become one of the important factors to assess blood and cardiovascular diseases. The interest on blood studies have promoted a development of various microfluidic devices that treat and analyse blood cells. Recent years, besides the RBC deformability assessment, these devices are often applied to cancer cell detection and isolation from the whole blood. The devices for can...
Visualization and measurement of red blood cells flowing in microfluidic devices
Rodrigues, Raquel; Pinho, Diana; Faustino, Vera; Yaginuma, T.; Bento, David; Fernandes, Carla S.; Garcia, Valdemar; Lima, R.Several experimental techniques were performed in the past years using in vitro environments, in an attempt to not only understand the blood flow behaviour in microcirculation but also develop microfluidic devices as an alternative clinical methodology to detect blood diseases. Hence, the visualization and measurement of red blood cells (RBCs) flowing in a microfluidic device are important to provide not only e...
Flow of red blood cells in microchannel networks : in vitro studies
Cidre, Diana; Rodrigues, Raquel O.; Faustino, Vera; Pinto, Elmano; Pinho, Diana; Bento, David; Correia, Teresa; Fernandes, Carla S.; Dias, Ricardo P.Blood exhibits unique flow characteristics on micro-scale level, due to the complex biochemical structure of Red Blood Cells (RBCs) and their response to both shear and extensional flow, which influence the rheological properties and flow behavior of blood [1,2]. In the past years, several in vitro studies where made and have revealed some physiologically significant phenomena, such as Fahraeus and Fahraeus-Lin...
Flow of red blood cells in microchannel networks: in vitro studies
Cidre, Diana; Rodrigues, Raquel O.; Faustino, Vera; Pinto, Elmano; Pinho, Diana; Bento, David; Fernandes, Carla S.; Dias, Ricardo P.; Lima, R.Blood exhibits unique flow characteristics on micro-scale level, due to the complex biochemical structure of Red Blood Cells (RBCs) and their response to both shear and extensional flow, which influence the rheological properties and flow behavior of blood [1,2]. In the past years, several in vitro studies where made and have revealed some physiologically significant phenomena, such as Fahraeus and Fahraeus-Lin...
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