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Toxicology of metals and metalloids
Barbosa Jr, Fernando; Farina, Marcelo; Viegas, Susana; Kempinas, Wilma de GravaMetal toxicology is one of the oldest areas of study of toxicology and one of the oldest environmental problems. Metals and metalloids are toxic elements at the top of the priority list of hazardous substances of the Agency for Toxic Substances and Disease Registry (ATSDR). However, several gaps of knowledge still exist that are related to their toxicity, mainly concerning the mechanisms of action. This special...
Involvement of glutamate and reactive oxygen species in methylmercury neurotoxi...
Aschner, Michael; Syversen, Tore; Souza, Diogo Onofre Gomes de; Rocha, Joao Batista Teixeira da; Farina, MarceloThis review addresses the mechanisms of methylmercury (MeHg)- induced neurotoxicity, specifically examining the role of oxidative stress in mediating neuronal damage. A number of critical findings point to a central role for astrocytes in mediating MeHg-induced neurotoxicity as evidenced by the following observations: a) MeHg preferentially accumulates in astrocytes; b) MeHg specifically inhibits glutamate upta...
Importance of the lipid peroxidation biomarkers and methodological aspects FOR ...
Grotto,Denise; Maria,Lucas Santa; Valentini,Juliana; Paniz,Clóvis; Schmitt,Gabriela; Garcia,Solange Cristina; Pomblum,Valdeci JuarezFree radicals induce lipid peroxidation, playing an important role in pathological processes. The injury mediated by free radicals can be measured by conjugated dienes, malondialdehyde, 4-hydroxynonenal, and others. However, malondialdehyde has been pointed out as the main product to evaluate lipid peroxidation. Most assays determine malondialdehyde by its reaction with thiobarbituric acid, which can be measure...
Diphenyl diselenide, a simple glutathione peroxidase mimetic, inhibits human LD...
Bem, Andreza Fabro de; Farina, Marcelo; Portella, Rafael de Lima; Nogueira, Cristina Wayne; Dinis, Teresa C. P.; Laranjinha, João A. N.Oxidative modification of low-density lipoprotein (LDL) represents an important factor in atherogenesis. In the present study, we have investigated the antioxidant capability of diphenyl diselenide (PhSe)2, a simple organoseleno compound, against copper (Cu2+) and peroxyl radical-induced human LDL oxidation in vitro. In initial studies using human serum, (PhSe)2 caused a dose-dependent inhibition of Cu2+-induce...
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