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Antiangiogénicos na Degenerescência Macular Relacionada com a Idade: a medicina...

Faria de Abreu, JR; Silva, R; Cachulo, ML; Figueira, J; Pires, I; Fonseca, P; Murta, JN


Chorioretinal anastomosis and photodynamic therapy:a two-year follow-up study

Silva, RM; Figueira, J; Cachulo, ML; Duarte, L; Faria de Abreu, JR; Cunha-Vaz, JG

BACKGROUND: To evaluate the two-year efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomosis (CRA). METHODS: A non-randomized, institutional, prospective study, of 28 consecutive eyes of 23 patients, with CRA, treated with PDT. Masked best corrected visual acuity (VA) and angiographic features at baseline and during the perio...


Polypoidal choroidal vasculopathy and photodynamic therapy with verteporfin

Silva, RM; Figueira, J; Cachulo, ML; Duarte, L; Faria de Abreu, JR; Cunha-Vaz, JG

BACKGROUND: We evaluated, in a nonrandomised, institutional, prospective study, the efficacy of photodynamic therapy (PDT) with verteporfin in age-related macular degeneration (AMD) eyes with polypoidal choroidal vasculopathy (PCV) and subfoveal exudation. METHODS: A prospective clinical and angiographic study was done in 40 consecutive eyes with PCV treated with PDT using masked best-corrected visual acuity (V...


Stabilization of visual acuity with photodynamic therapy in eyes with chorioret...

Silva, RM; Faria de Abreu, JR; Travassos, A; Cunha-Vaz, JG

PURPOSE: (1) To evaluate, in a non-randomized, institutional, prospective study, the efficacy of photodynamic therapy with Visudyne (PDT) in neovascular age-related macular degeneration (AMD) eyes with chorioretinal anastomoses (CRA). (2) To review, in a retrospective study and for comparison, the natural evolution of neovascular AMD eyes with CRA. METHODS: Prospective clinical and angiographic study of 17 con...


One-year follow-up of blood-retinal barrier and retinal thickness alterations i...

Lobo, CL; Bernardes, RC; Faria de Abreu, JR; Cunha-Vaz, JG

OBJECTIVE: To examine the 1-year alterations of the blood-retinal barrier and changes in retinal thickness occurring in the macular region in patients with type 2 diabetes mellitus and mild nonproliferative retinopathy. METHODS: We classified 12 eyes of 12 patients with type 2 diabetes mellitus and mild nonproliferative retinopathy by 7-field stereoscopic fundus photography, levels 20 and 35 of Wisconsin gradi...


Novel imaging techniques for diabetic macular edema

Lobo, CL; Bernardes, RC; Faria de Abreu, JR; Cunha-Vaz, JG

Retinal edema should be defined as any increase of water of the retinal tissue resulting in an increase in its volume. It may be of cytotoxic or vasogenic origin. Development of vasogenic macular edema is dependent on a series of factors such as blood pressure, blood-retinal barrier permeability, retinal cell damage, retinal tissue osmotic pressure and retinal tissue compliance. Objective measurements of retina...


Progression of retinopathy and alteration of the blood-retinal barrier in patie...

Cunha-Vaz, JG; Lobo, CL; Sousa, JC; Leite, E; Faria de Abreu, JR

BACKGROUND: The study was carried out to evaluate the correlation between blood-retinal barrier (BRB) permeability and the progression of diabetic retinopathy (DR), defined by development of "need for photocoagulation", over a 7-year period by means of vitreous fluorometry (VF). METHODS: Forty type 2 diabetic patients with minimal or no retinopathy, aged 40-65 years (mean 53.9 + 7.3 years), were followed up pro...


Blood-retinal barrier permeability and its relation to progression of retinopat...

Cunha-Vaz, JG; Leite, E; Sousa, JC; Faria de Abreu, JR

Forty patients with late-onset diabetes (age at diagnosis 30 years or more) and minimal retinopathy as found by fundus photography were followed prospectively by repeated examination (baseline, 1 year, and 4 years). The study shows that early retinopathy changes are not permanent or invariably progressive. In the 1st year of follow-up microaneurysms worsened in 25%, improved in 10%, and remained stabilized in 6...


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    Financiadores do RCAAP

Fundação para a Ciência e a Tecnologia Universidade do Minho   Governo Português Ministério da Educação e Ciência Programa Operacional da Sociedade do Conhecimento União Europeia