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Biological activity of heterologous murine interleukin-10 and preliminary studi...
Carvalho, Vera; Castanheira, Pedro; Faria, Tiago Q.; Gonçalves, Catarina; Madureira, Pedro; Faro, Carlos; Domingues, Lucília; Brito, Rui M. M.Interleukin-10 (IL-10) is an anti-inflammatory cytokine, which active form is a non-covalent homodimer with two intramolecular disulphide bonds essential for its biological activity. A mutated form of murine IL-10 was successfully expressed in E. coli, recovered and purified from inclusion bodies. Its ability to reduce tumor necrosis factor synthesis and down-regulate class II major histocompatibility complex...
Data: 2010
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Origem: RepositóriUM - Universidade do Minho
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