Encontrados 28 documentos, a visualizar página 1 de 3

On the use of dexamethasone-loaded liposomes to induce the osteogenic different...

Stem cells have received considerable attention by the scientific community because of their potential for tissue engineering and regenerative medicine. The most frequently used method to promote their differentiation is supplementation of the in vitro culture medium with growth/differentiation factors (GDFs). The limitations of that strategy caused by the short half-life of GDFs limit its efficacy in vivo and ...

Immobilization of bioactive factor-loaded liposomes at the surface of electrosp...

Publicado em "Journal of Tissue Engineering and Regenerative Medicine", vol. 7, supp. 1 (2013) ; The ability to manipulate and control the surface properties is of crucial importance in the designing of scaffolds for Tissue Engineering (TE) and Regenerative Medicine. Electrospun nanofibers (NFM), due to their morphology and fibrous structure have received much attention as potential biomedical devices, TE scaf...

Cognitive appraisal as a mediator in the relationship between stress and burnout

The relation between job stressors and burnout is well established in the literature. However, the mechanisms behind this relationship are still not clear. Thus, this study has the main goal of analysing the mediating role of cognitive appraisal on the relation between occupational stress and burnout. To test this relation, structural equation modelling was used in a sample of teachers (N=333) working at a publ...

O envolvimento familiar no processo de decisão dos jovens à saída do 9º ano.

A influência familiar nos projectos escolares e profissionais dos jovens pode fazer-se sentir de várias formas: transmitindo valores e informações sobre as profissões, actuando como modelo ou impondo uma profissão. Tem, em todo o caso, um papel inquestionável enquanto estruturante das decisões do adolescente, razão pela qual não pode deixar de ser equacionado na análise do processo de decisão vocacional. O pres...

Relationship of PON1 192 and 55 gene polymorphisms to calcific valvular aortic ...

Introduction and Objectives - Paraoxonases may exert anti-atherogenic action by reducing lipid peroxidation. Previous studies examined associations between polymorphisms in the paraoxonase 1 (PON1) gene and development of coronary artery disease (CAD), with inconsistent results. Given the similarities in clinical and pathophysiological risk factors of CAD and calcific aortic valve stenosis (CAVS), we postulated...

Implementação e validação de um método para determinação de contaminantes em vi...

Cada vez mais começa a notar-se, na indústria vitivinícola, uma grande preocupação com a qualidade dos seus produtos, motivada pela maior sensibilização e exigência dos consumidores. Deste modo, a presença de defeitos organoléticos no vinho representa uma fonte de perda financeira nesta indústria, pelo que o seu controlo se torna indispensável para que se obtenha um produto de elevada qualidade. Neste sentido, ...

Induction of human mesenchymal stem cells osteogenesis by bioactive agent-relea...

Stem cell therapy is a rapidly evolving area of research in regenerative medicine. Mesenchymal stem cells (MSCs) have received considerable attention by the scientific community because of their potential of expansion and the ability to differentiate into various mesodermal tissues. Liposomes are well-established non-viral carrier systems, presenting significant advantages over other nanoparticle-based drug del...

Modelos de mistura : aplicações em análise de regressão

Tese de doutoramento. Ciências de Engenharia. 2005. Faculdade de Engenharia. Universidade do Porto

Influence of conditioned medium over the chondrogenic differentiation of adult ...

The influence of patterned nanofiber meshes on human mesenchymal stem cell oste...

A specially designed electroconductive collector enables the electrospinning of P-NFM composed of areas of parallel/uniaxially aligned fibers and areas of random/orthogonal nanofiber distribution. The biological relevance of P-NFM is demonstrated using hBMSCs as an autologous cell source. The structures induce cell orientation along the uniaxially aligned fibers, mainly during earlier culturing periods under ba...