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Lichenicidin biosynthesis: LicP protease specificity

The lantibiotics are ribosomally synthesized peptides produced by Gram-positive cells that have antibiotic or morphogenic activity. After translation, the lantibiotics undergo chemical changes that result in the formation of unusual amino acids (lanthionine and methylanthionine), as well as the establishment of chemical bonds that confer a polycyclic structure to the peptide chain. After modifications occur, th...