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Using genomics for drug discovery in medulloblastoma

Tese de doutoramento, Medicina (Neurocirurgia), Universidade de Lisboa, Faculdade de Medicina, 2014 ; Medulloblastoma is the most common malignant brain tumor in childhood. The standard of care to treat patients with medulloblastoma includes surgical resection, craniospinal irradiaton (in children older than 3 years of age) and high dose chemotherapy. Overall survival rates for patients submitted to convention...