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Off-Label Prescribing: Scientific Analysis Taking the Use of Bevacizumab in Oph...
Off-label prescribing poses specific technical/scientific, professional and ethical problems. In this study we carry out a technical and scientific analysis of the off-label prescribing using a current, clinical and economically relevant example: the paradigmatic case of the use of bevacizumab in ophthalmologic pathologies for which it has no formal indication. We conducted a systematic review of the literature...
Generalization of the results of clinical studies through the analysis of subgr...
Costa, João; Fareleira, Filipa; Ascensão, Raquel; Vaz Carneiro, AntónioSubgroup analysis in clinical trials are usually performed to define the potential heterogeneity of treatment effect in relation with the baseline risk, physiopathology, practical application of therapy or the under-utilization in clinical practice of effective interventions due to uncertainties of its benefit/risk ratio. When appropriately planned, subgroup analysis are a valid methodology the define benefits ...
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