Encontrados 3 documentos, a visualizar página 1 de 1
Synergistic impact of endurance training and intermittent hypobaric hypoxia on ...
Magalhães, J.; Falcão-Pires, I.; Gonçalves, I. O.; Lumini-Oliveira, J.; Marques-Aleixo, I.; Passos, E. dos; Rocha-Rodrigues, S.; Machado, N. G.Background Intermittent hypobaric-hypoxia (IHH) and endurance-training (ET) are cardioprotective strategies against stress-stimuli. Mitochondrial modulation appears to be an important step of the process. This study aimed to analyze whether a combination of these approaches provides additive or synergistic effects improving heart-mitochondrial and cardiac-function. Methods Two-sets of rats were divided into no...
Modulation of myocardial stiffness by beta-adrenergic stimulation - its role in...
Falcão-Pires, I.; Sousa, Adelino Fontes; Conceiçao, L. Lopes; Brás-Silva, Carmen; Leite-Moreira, AdelinoThe acute effects of beta-adrenergic stimulation on myocardial stiffness were evaluated. New-Zealand white rabbits were treated with saline (control group) or doxorubicin to induce heart failure (HF) (DOXO-HF group). Effects of isoprenaline (10(-10)-10(-5) M), a non-selective beta-adrenergic agonist, were tested in papillary muscles from both groups. In the control group, the effects of isoprenaline were also e...
Apelin decreases myocardial injury and improves right ventricular function in m...
Falcão-Pires, I; Gonçalves, N; Henriques-Coelho, T; Moreira-Gonçalves, D; Roncon-Albuquerque R, Jr.; Leite-Moreira, AFWe investigated the endogenous production of apelin and the cardiac and pulmonary effects of its chronic administration in monocrotaline (MCT)-induced pulmonary hypertension (PH). Male Wistar rats were injected with MCT (60 mg/kg sc) or vehicle (day 0). One week later, these animals were randomly treated during 17 days with pyroglutamylated apelin-13 (Pyr-AP13; 200 microg*kg(-1)*day(-1) ip) or a similar volume ...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||