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Hydrophilic and hydrophobic cyclodextrins in a new sustained release oral formu...
Fernandes, Catarina Marques; Ramos, Pedro; Falcão, Amílcar Celta; Veiga, Francisco José BaptistaThe feasibility of using complexes with cyclodextrins (CDs) in nicardipine (NC) controlled delivery has been examined, with a view to extending the pharmaceutical applications spectrum of these carriers. For a fast release fraction, a hydrophilic [beta]-cyclodextrin derivative (hydroxypropyl-[beta]-cyclodextrin) was employed to form a water-soluble complex. For the sustained-releasing portion, triacetyl-[beta]-...
Data: 2003
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Origem: Estudo Geral - Universidade de Coimbra
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