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Performance of gentamicin population kinetic parameters in Portuguese neonates
Rocha, Marília J.; Almeida, Anabela M.; Falcão, Amílcar C.; Caramona, Margarida M.Aim: To evaluate the performance of eight different sets of gentamicin populational pharmacokinetic parameters, regarding potential implementation in clinical pharmacokinetic software as prior information. Methods: The study involved 49 patients of 31.3±4.1 weeks of gestational age (GA), receiving gentamicin, and for whom peak and trough concentrations were obtained. Accuracy and precision were assessed by mean...
Cyclodextrin multicomponent complexation and controlled release delivery strate...
Ribeiro, Laura S. S.; Falcão, Amílcar C.; Patrício, João A. B.; Ferreira, Domingos C.; Veiga, Francisco J. B.In the present work, to maintain a suitable blood level of vinpocetine (VP) for a long period of time, VP-cyclodextrin-tartaric acid multicomponent complexes were prepared and formulated in hydroxypropylmethylcellulose matrix tablets. In vitro and in vivo performances of these formulations were investigated over a VP immediate release dosage form. Solubility studies were performed to evaluate the drug pH solubi...
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