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The maximal electroshock seizure (MES) model in the preclinical assessment of p...
Castel-Branco, M. M.; Alves, G. L.; Figueiredo, I. V.; Falcão, A. C.; Caramona, M. M.The choice of appropriate animal models for the initial in vivo testing of potential anticonvulsant compounds is one of the most important steps in the successful search for new antiepileptic drugs. The purpose of this paper is to describe the most important aspects to take into account when performing the maximal electroshock seizure (MES) test in the routine laboratory screening of new antiepileptics: the con...
Lamotrigine pharmacokinetic evaluation in epileptic patients submitted to VEEG ...
Almeida, A. M.; Falcão, A. C.; Sales, F.; Baldeiras, I.; Rocha, M. J.; Caramona, M. M.Objective: The aim of the present study was to evaluate the pharmacokinetic profile of lamotrigine (LTG) in epileptic patients submitted to video-electroencephalography (VEEG) monitoring and, in addition, to investigate the influence of concomitant antiepileptic drugs (AEDs) on the kinetics of LTG. Methods: The analysis assumed a one-compartment open model with first-order absorption and elimination. The kineti...
Monitoring serum levels of gentamicin in neonates.
Rocha, M J; Almeida, A M; Afonso, E; Martins, V; Leitão, F; Santos, J; Falcão, A CNewborn infants in intensive care units demonstrated a higher incidence of gestational age below 31 week. Obstetrical and neonatal diseases procedures required for the management of critically ill neonates are associated with an increased risk of infections. Gentamicin is an aminoglycoside antibiotic often used to treat gram-negative bacillary infections and suspected sepsis in neonates. The risk of toxicity or...
Lamotrigine analysis in blood and brain by high-performance liquid chromatography
Castel-Branco, M. M.; Almeida, A. M.; Falcão, A. C.; Macedo, T. A.; Caramona, M. M.; Lopez, F. G.A reversed-phase high-performance liquid chromatography assay was developed and validated to determine plasma and brain lamotrigine concentrations allowing pharmacokinetic-pharmacodynamic studies of this new antiepileptic drug in patients and laboratory animals. Lamotrigine and its internal standard were extracted, under alkaline conditions, from plasma and brain homogenate, into ethyl acetate; brain proteins w...
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