Dissertação de Mestrado apresentada ao ISPA - Instituto Universitário, na especialidade de Psicologia Social e das Organizações. ; O presente estudo tem como finalidade estudar três variáveis que influenciam a aprendizagem nas organizações. Mais concretamente, pretende-se analisar a relação entre o estilo de gestão de conflitos utilizado (valores cooperativos vs valores competitivos) e a forma como as tarefas ...
The vitamin D receptor (VDR) gene is a candidate gene for susceptibility to autoimmune disorders. Association studies of VDR polymorphisms and risk of type 1 diabetes often produced conflicting results in different ethnic backgrounds. The aim of this study was to test for association between common VDR polymorphisms and the genetic susceptibility to type 1 diabetes in the Portuguese population. We genotyped 207...
Thyroid Lymphomas are rare tumors among thyroid neoplasms. Almost all types originate from B cells and the most frequent subtype is a diffuse large cell lymphoma. The majority arise in a background of Hashimoto's thyroiditis and patients present with a thyroid mass, rapidly enlarging and with pressure symptoms. The treatment depends on the histological subtype and stage of the disease but include radiotherapy a...
The contributions of hepatic glycogenolysis to fasting glucose production and direct pathway to hepatic glycogen synthesis were quantified in eight type 1 diabetic patients and nine healthy control subjects by ingestion of (2)H(2)O and acetaminophen before breakfast followed by analysis of urinary water and acetaminophen glucuronide. After overnight fasting, enrichment of glucuronide position 5 relative to body...
The contribution of gluconeogenesis to fasting glucose production was determined by a simple measurement of urinary menthol glucuronide (MG) 2H enrichment from 2H2O. Following ingestion of 2H2O (0.5% body water) during an overnight fast and a pharmacological dose (400 mg) of a commercial peppermint oil preparation the next morning, 364 mumol MG was quantitatively recovered from a 2-h urine collection by ether e...
Friedreich's ataxia (FA) is one of the genetic syndromes sometimes associated with diabetes and the most common hereditary ataxia. It is a autosomal recessive neurodegenerative disease, caused by a mutation in the FRDA gene, which originates decreased expression of frataxin, a mitochondrial protein involved in iron metabolism. The disorder is usually manifest in childhood and is characterised by ataxia, dysarth...
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