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Parotidite recorrente juvenil… nem sempre é o que parece
Sá, A.; Fraga, J.; Costa, A.M.; Dias, F.; Brito, I.RESUMO Introdução: A parotidite recorrente juvenil (PRJ) é uma inflamação recidivante idiopática da glândula parótida, geralmente associada a sialectasia não-obstrutiva. A síndrome de Sjögren (SS), rara em idade pediátrica, pode apresentar-se nesta faixa etária sob a forma de parotidites de repetição. Caso clínico: Menina, de 13 anos, que no quarto episódio de tumefação e dor parotídea, iniciou investigação eti...
Newborn screening for medium-chain acyl-CoA dehydrogenase deficiency: regional ...
Couce, M.L.; Sánchez-Pintos, P.; Diogo, L.; Leão-Teles, E.; Martins, E.; Santos, H.; Bueno, M.A.; Delgado-Pecellín, C.; Castiñeiras, D.E.; Cocho, J.A.BACKGROUND: Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is the most common inherited defect in the mitochondrial fatty acid oxidation pathway, resulting in significant morbidity and mortality in undiagnosed patients.Newborn screening (NBS) has considerably improved MCADD outcome, but the risk of complication remains in some patients. The aim of this study was to evaluate the relationship between geno...
Benefits of spine stabilization with biodegradable scaffolds in spinal cord inj...
Silva, Nuno; Sousa, R. A.; Fraga, J. S.; Fontes, Marco; Almeida, Hugo Leite; Cerqueira, R.; Almeida, Armando; Sousa, Nuno; Reis, R. L.; Salgado, A. J.Spine stabilization upon spinal cord injury (SCI) is a standard procedure in clinical practice, but rarely employed in experimental models. Moreover, the application of biodegradable biomaterials for this would come as an advantage as it would eliminate the presence of a nondegradable prosthesis within the vertebral bone. Therefore, in the present work, we propose the use of a new biodegradable device specifica...
Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...
Silva, Nuno; Rodrigues, Ana João; Sousa, Nuno; Salgado, A. J.; Fraga, J. S.; Reis, R. L.; Manadas, B.It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...
Newborn screening for medium-chain acyl-CoA dehydrogenase deficiency: regional ...
Couce, M.; Sánchez-Pintos, P.; Diogo, L.; Leão-Teles, E.; Martins, E.; Santos, H.; Amor Bueno, M.; Delgado-Pecellín, C.; Castiñeiras, D.; Cocho, J.Background Medium-chain acyl-CoA dehydrogenase deficiency (MCADD) is the most common inherited defect in the mitochondrial fatty acid oxidation pathway, resulting in significant morbidity and mortality in undiagnosed patients. Newborn screening (NBS) has considerably improved MCADD outcome, but the risk of complication remains in some patients. The aim of this study was to evaluate the relationship between gen...
Unveiling the effects of the secretome of mesenchymal progenitors from the umbi...
Fraga, J. S.; Silva, N. A.; Lourenço, A. S.; Gonçalves, V.; Neves, N. M.; Reis, R. L.; Rodrigues, A. J.; Manadas, B.; Sousa, N.; Salgado, A. J.It has been previously shown that the secretome of Human Umbilical Cord Perivascular Cells (HUCPVCs), known for their mesenchymal like stem cell character, is able to increase the metabolic viability and hippocampal neuronal cell densities. However, due to the different micro-environments of the distinct brain regions it is important to study if neurons isolated from different areas have similar, or opposite, r...
Miosite orbitária numa criança
Fraga, J.; Sá, A.; Cândido, C.; Pinto, J.; Dias, F.Introdução: A doença inflamatória orbitária caracteriza-se por um processo inflamatório, de etiologia desconhecida, que pode atingir qualquer estrutura da órbita. Apresentamos um caso clínico da forma que envolve os músculos extraoculares (miosite orbitária). Caso clínico: Criança do sexo masculino com nove anos de idade, sem antecedentes patológicos de relevo, que iniciou subitamente dor ocular à direita, acom...
The secretome of stem cells isolated from the adipose tissue and wharton jelly ...
Ribeiro, Carlos A.; Fraga, J. S.; Grãos, Mário; Neves, N. M.; Reis, R. L.; Sousa, Nuno; Salgado, A. J.; Gimble, Jeffrey M.Introduction: It is hypothesized that administration of stromal/stem cells isolated from the adipose tissue (ASCs) and umbilical cord (HUCPVCs) can ameliorate the inured CNS. However it is still not clear whether they have similar or opposite effects on primary cultures of neuronal populations. The objective of the present work was to determine if ASCs and HUCPVCs preferentially act, or not, on specific cell po...
Prevenção de acidentes: o que sabem os pais
Costa, A.; Sá, A.; Fraga, J.; Dias, F.; Serafim, M.J.Introdução: Os acidentes domésticos e rodoviários são causa frequente de morbilidade e mortalidade infantil. Objectivo: avaliar o conhecimento das normas de segurança infantil por parte dos pais, tendo em conta o grau de habilitações académicas (Ensino Básico (B), Ensino Secundário (S), Ensino Superior (SU)). Material e métodos: Estudo transversal com aplicação de um inquérito aos pais de crianças entre os 9 me...
In vivo biodistribution of carboxymethylchitosan/poly(amidoamine) dendrimer nan...
Pereira, Vitor H.; Salgado, A. J.; Oliveira, Joaquim M.; Cerqueira, Susana R.; Frias, A. M.; Fraga, J. S.; Roque, Susana; Falcão, Ana M.Carboxymethylchitosan/poly(amidoamine) dendrimer nanoparticles (CMCht/PAMAM) have recently been proposed for intracellular drug delivery purposes. These are constituted by a PAMAM dendrimer core grafted with chains of CMCht. Previous reports have shown that these nanoparticles disclosed an improved cytotoxic profile when compared to traditional dendrimers. Following on these results the present study aims to as...
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