Encontrados 342 documentos, a visualizar página 1 de 35
Efectividade da Rede de Referenciação Perinatal da Região Centro
Costa, E.; Moleiro, P.; Carvalho, L.; Neves, F.; Oliveira, J.; Ventura, A.; Teixeira, A. L.; Martins, J.; Figueiredo, N.; Costa, R.; Peixoto, J.Resumo Em 1990 foi desenvolvida em Portugal uma Rede de Referenciação Perinalal, com definição dos limites e as responsabilidades assistenciais dos Hospitais de Apoio Perinatal Diferenciado (HAPD) e dos Hospitais de Apoio Perinatal (HAP). Graças ao espírito de cooperação c complementaridade desenvolvidos, os critérios de transferência iu útero e pós natal estão bem estabelecidos* Com os resultados do Registo Na...
Docking studies in target proteins involved in mechanisms of antibacterial acti...
Alves, Maria José; Froufe, Hugo J.C.; Costa, Ana F.T.; Santos, Anabela F.; Oliveira, Liliana G.; Osório, Sara R.M.; Abreu, Rui M.V.; Pintado, ManuelaIn the present work, the knowledge on target proteins of standard antibiotics was extended to antimicrobial mushroom compounds. Docking studies were performed for 34 compounds in order to evaluate their affinity to bacterial proteins that are known targets for some antibiotics with different mechanism of action: inhibitors of cell wall synthesis, inhibitors of protein synthesis, inhibitors of nucleic acids synt...
Malformação Quística Adenomatoideia Congénita Pulmonar. Duas Formas de Apresent...
Carral, Carmen; Koehler, Susana; Araújo, João; Cunha, J.; Santos, F.; Oliveira, D.; Moura, E.; Almeida, E.; J. Oliveira, M.; Ferreira, P.; Frutuoso, S.A malformação quística adenometoideia congénita do pulmão consiste numa massa de quistos revestidos por epitélio respiratório resultante da proliferação dos bronquíolos terminais.A sua apresentação clínica é muito diversa, desde casos de morte fetal por hidrops não imune até quadros de infecções pulmonares recorrentes na infância.Os autores descrevem dois casos clínicos de malformação quística adenomatoideia co...
Higiene genital feminina
Ferreira, F; Oliveira, A; Dantas, FIntrodução: A saúde genitourinária da mulher encontra-se diretamente relacionada com a sua higiene íntima diária. O conhecimento da anatomia da mulher, fases do ciclo menstrual e do ciclo de vida da mulher, melhoram a capacidade de cada mulher promover uma higiene íntima diária adequada à sua fase da vida. Objetivos: Informar sobre os cuidados diários de higiene genital feminina Transmitir conselhos práticos so...
Synaptic Transmission: Looking for Clues to Autism Spectrum Disorders (ASD) Eti...
Oliveira, B.A.; Correia, C.A.; Conceição, I.C.; Café, C.; Almeida, J.; Mouga, S.; Duque, F.; Oliveira, G.; Vicente, A.M.Copy Number Variants (CNVs) play an important role in susceptibility to ASD, often mediated by the deletion or duplication of genes involved in synaptic structure and function. Increasing evidence suggests a central role for defects in synaptic structure and function in the pathogenesis of non-syndromic ASD. In this study we tested the hypothesis of an enrichment in CNVs encompassing synaptic transmission genes...
Bioactive macro/micro porous silk fibroin/Nano-sized calcium phosphate scaffold...
Yan, Leping; Correia, Joana Silva; Correia, C.; Caridade, S. G.; Fernandes, E. M.; Sousa, R. A.; Mano, J. F.; Oliveira, Joaquim M.; Oliveira, A. L.Aim: The development of novel silk/nano-sized calcium phosphate (silk/nano-CaP) scaffolds with highly dispersed CaP nanoparticles in the silk fibroin (SF) matrix for bone tissue engineering. Materials & methods: Nano-CaP was incorporated in a concentrated aqueous SF solution (16 wt.%) by using an in situ synthesis method. The silk/nano-CaP scaffolds were then prepared through a combination of salt-leaching/ lyo...
Cryopreservation of cell laden natural origin hydrogels for cartilage regenerat...
Popa, Elena G.; Rodrigues, Márcia T.; Coutinho, Daniela F.; Oliveira, Mariana B.; Mano, J. F.; Reis, R. L.; Gomes, Manuela E.The time span needed for obtaining a functional cartilage substitute using tissue engineering strategies, together with the need for specific patient oriented constructs has stimulated the growing interest for developing “off-the shelf” products. One way to deliver such products is based on long-term storage processes, such as cryopreservation, that will provide the clinical substitute available as needed and c...
Rheological and mechanical properties of acellular and cellladen methacrylated ...
Silva-Correia, J.; Gloria, A.; Oliveira, M. B.; Mano, J. F.; Oliveira, Joaquim M.; Ambrosio, L.; Reis, R. L.Tissue engineered hydrogels hold great potential as nucleus pulposus substitutes (NP), as they promote intervertebral disc (IVD) regeneration and re-establish its original function. But, the key to their success in future clinical applications greatly depends on its ability to replicate the native 3D micro-environment and circumvent their limitation in terms of mechanical performance. In the present study, we i...
Silk-Fibroin/Methacrylated Gellan Gum Hydrogel as an novel scaffold for applica...
Pereira, H.; Correia, Joana Silva; Yan, Leping; Caridade, S. G.; Frias, A. M.; Oliveira, A. L.; Mano, J. F.; Oliveira, Joaquim M.Introduction: Knee meniscus injury is highly prevalent and there is a demand for new cost-effective treatment solutions. Tissue engineering (TE) and regenerative medicine strategies using acellular scaffolds are being used in clinical application for total or partial meniscus replacement [1]. Although this strategy has been considered as a safe and promising approach, progressive volume reduction of the implant...
A new anti-feedant clerodane diterpenoid from tinospora cordifolia
Sivasubramanian, Aravind; Narasimha, Krishna Kumari Gadepalli; Rathnasamy, Rishikesan; Campos, Ana M. F. OliveiraPhytochemical investigation of the chloroform extract of Tinospora cordifolia yielded a new clerodane diterpenoid tincordin (1) along with tinosporide (2), 8-hydroxytinosporide (3), columbin (4), 8-hydroxycolumbin (5) and 10-hydroxycolumbin (6). The structure of the new compound was elucidated comprehensively using 1D and 2D NMR methods. All major clerodane diterpenoids isolated were tested for their efficacy a...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||