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Nematode and Arthropod Genomes Provide New Insights into the Evolution of Class...
Cardoso, J. C. R.; Félix, Rute C.; Power, DeborahNematodes and arthropods are the most speciose animal groups and possess Class 2 B1 G-protein coupled receptors (GPCRs). Existing models of invertebrate Class 2 B1 GPCR evolution are mainly centered on Caenorhabditis elegans and Drosophila melanogaster and a few other nematode and arthropod representatives. The present study reevaluates the evolution of metazoan Class 2 B1 GPCRs and orthologues by exploring the...
Feeding and the rhodopsin family g-protein coupled receptors in nematodes and a...
Cardoso, J. C. R.; Félix, Rute C.; Fonseca, Vera G.; Power, DeborahIn vertebrates, receptors of the rhodopsin G-protein coupled superfamily (GPCRs) play an important role in the regulation of feeding and energy homeostasis and are activated by peptide hormones produced in the brain-gut axis.These peptides regulate appetite and energy expenditure by promoting or inhibiting food intake. Sequence and function homologs of human GPCRs involved in feeding exist in the nematode round...
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