Encontrados 6 documentos, a visualizar página 1 de 1
Nematode and Arthropod Genomes Provide New Insights into the Evolution of Class...
Cardoso, J. C. R.; Félix, Rute C.; Power, DeborahNematodes and arthropods are the most speciose animal groups and possess Class 2 B1 G-protein coupled receptors (GPCRs). Existing models of invertebrate Class 2 B1 GPCR evolution are mainly centered on Caenorhabditis elegans and Drosophila melanogaster and a few other nematode and arthropod representatives. The present study reevaluates the evolution of metazoan Class 2 B1 GPCRs and orthologues by exploring the...
Feeding and the rhodopsin family g-protein coupled receptors in nematodes and a...
Cardoso, J. C. R.; Félix, Rute C.; Fonseca, Vera G.; Power, DeborahIn vertebrates, receptors of the rhodopsin G-protein coupled superfamily (GPCRs) play an important role in the regulation of feeding and energy homeostasis and are activated by peptide hormones produced in the brain-gut axis.These peptides regulate appetite and energy expenditure by promoting or inhibiting food intake. Sequence and function homologs of human GPCRs involved in feeding exist in the nematode round...
The role of detoxification in the mosquito Anopheles gambiae response to Plasmo...
Felix, Rute, CasteloRute C. Félix PALAVRAS-CHAVE: Malária, mosquito vector, Anopheles gambiae, parasita, Plasmodium berghei, infecção, enzimas de detoxificação, citocromos P450, tubulinas A malária, uma das doenças mais devastadoras que ocorrem em África é causada por um parasita do género Plasmodium e é transmitida aos humanos por mosquitos vectores do género Anopheles durante a refeição de sangue. Apesar da resposta do mosquito ...
A chemotaxis operon in the bacterium Desulfovibrio gigas is induced under sever...
Félix, Rute; Rodrigues, Rute; Machado, Patrícia; Oliveira, Solange; Rodrigues-Pousada, ClaudinaAbstract: The chemosensory system of bacteria controls their motility and behaviour in different environments. In the present study, we report the identification of the first chemotaxis operon in Desulfovibrio gigas. Amino acid sequence analysis revealed seven coding regions for polypeptides with a high similarity to chemotaxis proteins from other organisms. D. gigas chemotaxis operon has a similar genetic orga...
Characterization and expression analysis of the cytochrome bd oxidase operon fr...
Machado, Patrícia; Félix, Rute; Rodrigues, Rute; Oliveira, Solange; Rodrigues-Pousada, ClaudinaAbstract: Although classified as anaerobic, Desulfovibrio gigas contains a functional canonical membrane respiratory chain, including a cytochrome bd quinol oxidase as its terminal element. In the present study, we report the identification of the operon cydAB encoding the two subunits of cytochrome bd from this bacterium. Two hypothetical promoter regions and sequences resembling transcriptional regulators-bin...
Desulfovibrio gigas flavodiiron protein affords protection against nitrosative ...
Rodrigues, Rute; Vicente, João B.; Félix, Rute; Oliveira, Solange; Teixeira, Miguel; Rodrigues-Pousada, ClaudinaAbstract: Desulfovibrio gigas flavodiiron protein (FDP), rubredoxin: oxygen oxidoreductase (ROO), was proposed to be the terminal oxidase of a soluble electron transfer chain coupling NADH oxidation to oxygen reduction. However, several members from the FDP family, to which ROO belongs, revealed nitric oxide (NO) reductase activity. Therefore, the protection afforded by ROO against the cytotoxic effects of NO w...
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