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Projeto cuidar em parceria: nós cuidamos em parceria – Serviço de Neurologia

Developing a Food and Nutrition Quality Stamp for Public Restaurants in Portugal

[Abstract] ; [Resumo]

Desenvolvimento de selo de qualidade alimentar e nutricional para a restauração...

[Abstract] ; [Resumo]

Design, synthesis and neuroprotective evaluation of novel tacrine–benzothiazole...

Alzheimer’s disease (AD) is a multifactorial disorder with several target proteins contributing to its etiology. In search for multifunctional anti-AD drug candidates, taking into account that the acetylcholinesterase (AChE) and beta-amyloid (Aβ) aggregation are particularly important targets for inhibition, the tacrine and benzothiazole (BTA) moieties were conjugated with suitable linkers in a novel series of ...

Genetic Characterization of an Insect-Specific Flavivirus Isolated from Culex T...

We describe the full genetic characterization of an insect-specific flavivirus (ISF) from Culex theileri (Theobald) mosquitoes collected in Portugal. This represents the first isolation and full characterization of an ISF from Portuguese mosquitoes. The virus, designated CTFV, for Culex theileri flavivirus, was isolated in the C6/36 Stegomyia albopicta (=Aedes albopictus) cell line, and failed to replicate in v...

Phylogenetically and spatially close marine sponges harbour divergent bacterial...

Recent studies have unravelled the diversity of sponge-associated bacteria that may play essential roles in sponge health and metabolism. Nevertheless, our understanding of this microbiota remains limited to a few host species found in restricted geographical localities, and the extent to which the sponge host determines the composition of its own microbiome remains a matter of debate. We address bacterial abun...

Mitochondrial Dysfunction: The Road to Alpha-Synuclein Oligomerization in PD

While the etiology of Parkinson's disease remains largely elusive, there is accumulating evidence suggesting that mitochondrial dysfunction occurs prior to the onset of symptoms in Parkinson's disease. Mitochondria are remarkably primed to play a vital role in neuronal cell survival since they are key regulators of energy metabolism (as ATP producers), of intracellular calcium homeostasis, of NAD+/NADH ratio, a...

Caracterização da terapêutica não farmacológica dos utentes diabéticos de uma f...

A diabetes tipo 2 é uma doença metabólica que se estima que atinja 9,8% dos portugueses acima dos 20 anos. O reconhecimento de que o bom controlo glicémico permite reduzir de forma significativa as suas complicações estabeleceu como prioridade nestes doentes o tratamento eficaz da hiperglicemia. Na base do tratamento encontram-se as modificações dos estilos de vida, considerando-se a sobrenutrição e o sedentari...

Generation of hydrogen from chemical hydrides under pressure up to 70 Bar

Hydrogen production by sodium borohydride through hydrolysis in alkaline solutions has been extensively studied as a production/storage option. The potential application of this option is dependent on an easily controllable catalysed hydrolysis reaction at significant rates to comply with fuel cell feeding but also on the increase of the gravimetric density being of paramount importance, the design and implemen...

Aplasias Medulares Congénitas

Las aplasias medulares congénitas constituyen un grupo heterogéneo de enfermedades que se caracterizan por insuficiencia medular, asociadas frecuentemente a una o más anomalías somáticas y con riesgo elevado de neoplasias.Son enfermedades raras, generalmente diagnosticadas en la edad pediátrica, y con una mortalidad prematura importante. Los autores presentan 11 casos de aplasia medular congénita,8 deanemia de ...