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Directed evolution of activation-induced cytidine deaminase (AID) in its natura...

Tese de mestrado, Biologia (Biologia Humana e Ambiente), 2009, Universidade de Lisboa, Faculdade de Ciências ; Activation-induced cytidine deaminase (AID) is responsible for the induction of three reactions of DNA somatic modification employed by jawed vertebrates in the context of adaptive immunity: Somatic Hypermutation (SHM), Class Switch Recombination (CSR) and Immunoglobulin Gene Conversion (Ig GC). Howev...