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Gelatin microparticles aggregates as three-dimensional scaffolding system in ca...
García Cruz, D. M.; Sardinha, Vanessa Morais; Escobar Ivirico, J. L.; Mano, J. F.; Gómez Ribelles, J. L.A three-dimensional (3D) scaffolding system for chondrocytes culture has been produced by agglomeration of cells and gelatin microparticles with a mild centrifuging process. The diameter of the microparticles, around 10 μ, was selected to be in the order of magnitude of the chondrocytes. No gel was used to stabilize the construct that maintained consistency just because of cell and extracellular matrix (ECM) ad...
Proliferation and differentiation of goat bone marrow stromal cells in 3d scaff...
Escobar Ivirico, J. L.; Salmerón-Sánchez, M.; Gómez Ribelles, J. L.; Monleón Pradas, M.; Soria, Jose Miguel; Gomes, Manuela E.; Reis, R. L.; Mano, J. F.We have synthesized methacrylate-endcapped caprolactone networks with tailored water sorption ability, poly(CLMA-co-HEA), in the form of three-dimensional (3D) scaffolds with the same architecture but exhibiting different hydrophilicity character (xHEA50, 0.3, 0.5), and we investigated the interaction of goat bone marrow stromal cells (GBMSCs) with such structures. For this purpose, GBMSCs were seeded and cultu...
Chitosan microparticles as injectable scaffolds for tissue engineering
Garcia Cruz, Dunia M.; Escobar Ivirico, J. L.; Gomes, Manuela M.; Gómez Ribelles, J. L.; Salmerón-Sánchez, M.; Reis, R. L.; Mano, J. F.The use of chitosan microparticles as injectable carriers for cell transplantation represents a promising alternative to avoid the drawbacks of the implantation of other forms of three-dimensional (3D) scaffolds seeded with cells. In this study, a 3D construct is obtained in vitro by combining chitosan microparticles crosslinked with genipin and goat bone marrow stromal cells (GBMCs). Cell viability and the mor...
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