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Índice Proliferativo Ki-67 no Cancro Gástrico

Introdução: O cancro gástrico representa ainda uma das principais causas de mortalidade por doença oncológica a nível mundial, apesar da evolução substancial no seu tratamento. Diversos marcadores biológicos têm sido introduzidos com intuito prognóstico da doença. A proteína Ki-67 através de técnicas imunocitoquímicas tem sido utilizada como um indicador da actividade proliferativa tumoral. No cancro gástrico o...

Back analysis of geomechanical parameters in underground works using an evoluti...

The purpose of this work is to evaluate the performance of an optimization algorithm from the field of evolutionary computation, namely an Evolution Strategy, in back analysis of geomechanical parameters in underground structures. This analysis was carried out through a parametric study of a synthetic case of a tunnel construction. Different combinations of parameters and measurements were carried out to test t...

Multivariate analysis of walker-assisted ambulation

In an aging society it is extremely important to develop devices which can support and aid the elderly in their daily life. Walkers play an important role, due to the large number of potential users, its simplicity and their ambulatory potential. However, there are no clinical evidences that prove the efficacy of such devices, mainly rollators that present forearm supports. In this context, the authors aim to p...

Sensitivity analysis of a crawl gait multi-objective optimization system

This paper describes the analysis of a crawl gait multi-objective optimization system that combines bio-inspired Central Patterns Generators (CPGs) and a multi-objective evolutionary algorithm. In order to optimize the crawl gait, a multiobjective problem, an optimization system based on NSGAII allows to find a set of non-dominated solutions that correspond to different motor solutions The experimental results ...

On optimizing a WWTP design using multi-objective approaches

In this paper, the multi-objective formulation of an optimization problem arising from an activated sludge (AS) system of a wastewater treatment plant (WWTP) design optimization is solved through a multi-objective genetic algorithm. Two multi-objective approaches are proposed. First, a solution to the WWTP design is provided, regardless of its location, date of construction or the involved unit operations. The ...

Alterações fenotípicas e genéticas do metabolismo do ferro numa população portu...

Mathisson's helical motions for a spinning particle: Are they unphysical?

It has been asserted in the literature that Mathisson's helical motions are unphysical, with the argument that their radius can be arbitrarily large. We revisit Mathisson's helical motions of a free spinning particle, and observe that such statement is unfounded. Their radius is finite and confined to the disk of centroids. We argue that the helical motions are perfectly valid and physically equivalent descript...

Analysis of Genetic Markers for Cardiovascular Disorders in a Portuguese popula...

Familial Hypercholesterolaemia is a genetic disorder characterized by an increase in TC and LDLC leading to premature atherosclerosis (ATH) and cardiovascular disorders (CVD) but not all FH patients develops premature CVD. Early identification of FH patients at an even increased risk of developing CVD is important. Genetic markers could improve risk stratification for this patients. Inflammation has been consid...

Analysis of Genetic Markers for Cardiovascular Disorders in a Portuguese Popula...

Familial Hypercholesterolaemia (FH) is a genetic disorder that leads to an increase in levels of total and low density lipoprotein cholesterol promoting atherosclerosis (ATH) and premature cardiovascular disease (CVD). ATH and CVD are multifactorial disorders depending on both genetic and environmental factors and inflammation has been considered to be involved in the pathogenesis of ATH and CVD, namely the act...

Carcinoma Oculto da Mama com Metástases Axilares. A Propósito de Dois Casos Clí...

INTRODUÇÃO: O carcinoma oculto é uma entidade pouco frequente, que se define como a presença de metástases com tumor primário indetetável na altura da apresentação. O prognóstico da maioria dos casos de tumor oculto é reservado, no entanto, o desenvolvimento de técnicas imunohistoquímicas que permitem a caracterização do tumor, tornaram alguns subgrupos de tumor oculto potencialmente curáveis. A presença de a...