Background: Saccharomyces cerevisiae (Baker’s yeast) is found in diverse ecological niches and is characterized by high adaptive potential under challenging environments. In spite of recent advances on the study of yeast genome diversity, little is known about the underlying gene expression plasticity. In order to shed new light onto this biological question, we have compared transcriptome profiles of five envi...
Background: Genome variability generates phenotypic heterogeneity and is of relevance for adaptation to environmental change, but the extent of such variability in natural populations is still poorly understood. For example, selected Saccharomyces cerevisiae strains are variable at the ploidy level, have gene amplifications, changes in chromosome copy number, and gross chromosomal rearrangements. This suggests ...
A relação entre genótipo e fenótipo é altamente complexa. A acumulação de mutações e a adaptação dos microorganismos a diferentes condições ambientais resultam em importante diversidade genética que pode ser detectada como single nucleotide polymorphisms (SNPs), indels (delecções ou inserções), ou mesmo amplificações e alterações do número de cromossomas. A hibridação comparativa do genoma (aCGH, array Comparat...
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