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Phosphonocarboxylates inhibit the second geranylgeranyl addition by Rab geranyl...
Baron, RA.; Tavare, R.; Figueiredo, AC.; Blazewska, KM.; Kashemirov, BA.; McKenna, CE.; Ebetino, FH.; Taylor, A.; Rogers, MJ.; Coxon, FP.; Seabra, MC.Rab geranylgeranyl transferase (RGGT) catalyzes the post-translational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by a carboxylate (phosphonocarboxylate, PC). The phosphonocarboxylates used were 3-PEHPC, which was previously report...
Data: 2009
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Origem: ARCA - Access to Research and Communication Annals
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