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Postembryonic establishment of megabase-scale gene silencing in nucleolar domin...
Silva, Manuela; Viegas, Wanda; Pontes, Olga; Lawrence, Richard; Preuss, Sasha; Costa-Nunes, Pedro; Earley, Keith; Neves, Nuno; Pikaard, CraigNucleolar dominance is an epigenetic phenomenon in plant and animal genetic hybrids that describes the expression of 45S ribosomal RNA genes (rRNA genes) inherited from only one progenitor due to the silencing of the other progenitor’s rRNA genes. rRNA genes are tandemly arrayed at nucleolus organizer regions (NORs) that span millions of basepairs, thus gene silencing in nucleolar dominance occurs on a scale se...
Erasure of histone acetylation by Arabidopsis HDA6 mediates large-scale gene si...
Silva, Manuela; Viegas, Wanda; Earley, Keith; Lawrence, Richard; Pontes, Olga; Reuther, Rachel; Enciso, Angel; Neves, Nuno; Gross, MichaelNucleolar dominance describes the silencing of one parental set of ribosomal RNA (rRNA) genes in a genetic hybrid, an epigenetic phenomenon that occurs on a scale second only to X-chromosome inactivation in mammals. An RNA interference (RNAi) knockdown screen revealed that the predicted Arabidopsis histone deacetylase, HDA6, is required for rRNA gene silencing in nucleolar dominance. In vivo, derepression of si...
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