Encontrados 5 documentos, a visualizar página 1 de 1
GLUT1 and CAIX expression profiles in breast cancer correlate with adverse prog...
Pinheiro, Céline; Sousa, Bárbara; Albergaria, André; Paredes, Joana; Dufloth, Rozany; Vieira, Daniella; Schmitt, Fernando C.; Baltazar, FátimaWe thank Dr. Vitor Carneiro (pathologist from the Hospital do Divino Espírito Santo, Ponta Delgada, São Miguel, Azores), for his help in retrieving the breast cancer samples for this study. ; The goal of the present work was to evaluate the correlation of glucose transporter 1 (GLUT1) and carbonic anhydrase IX (CAIX) with the monocarboxylate transporters 1 (MCT1) and 4 (MCT4) and their chaperone, CD147, in bre...
Carcinoma de mama: novos conceitos na classificação
Vieira,Daniella Serafin Couto; Dufloth,Rozany Mucha; Schmitt,Fernando Carlos Lander; Zeferino,Luiz CarlosO carcinoma de mama é a neoplasia maligna mais comum em mulheres. Estudos moleculares do carcinoma de mama, baseados na identificação do perfil de expressão gênica por meio do cDNA microarray, permitiram definir pelo menos cinco sub-grupos distintos: luminal A, luminal B, superexpressão do HER2, basal e normal breast-like. A técnica de tissue microarray (TMA), descrita pela primeira vez em 1998, permitiu estuda...
Tissue microarrays for testing basal biomarkers in familial breast cancer cases
Dufloth,Rozany Mucha; Matos,Irina; Schmitt,Fernando; Zeferino,Luiz CarlosCONTEXT AND OBJECTIVE: The proteins p63, p-cadherin and CK5 are consistently expressed by the basal and myoepithelial cells of the breast, although their expression in sporadic and familial breast cancer cases has yet to be fully defined. The aim here was to study the basal immunopro-file of a breast cancer case series using tissue microarray technology. DESIGN AND SETTING: This was a cross-sectional study at U...
Analysis of BRCA1 and BRCA2 mutations in Brazilian breast cancer patients with ...
Dufloth,Rozany Mucha; Carvalho,Sílvia; Heinrich,Juliana Karina; Shinzato,Júlia Yoriko; Santos,César Cabello dos; Zeferino,Luiz Carlos; Schmitt,FernandoCONTEXT AND OBJECTIVE: BRCA1 and BRCA2 are the two principal hereditary breast cancer susceptibility genes, and the prevalence of their mutations among Brazilian women is unknown. The objective was to detect BRCA1 and BRCA2 mutations in Brazilian patients with breast cancer, so as to establish genetic profiles. DESIGN AND SETTING: Cross-sectional study, in Centro de Atenção Integral à Saúde da Mulher, Universid...
Desempenho do exame colpocitológico com revisão por diferentes observadores e d...
Santos,André Luís Ferreira; Derchain,Sophie Françoise Mauricette; Calvert,Evelyn Bartholo; Martins,Marcos Roberto; Dufloth,Rozany MuchaPara avaliar o desempenho da colpocitologia (CO) de encaminhamento e daquela coletada no serviço de referência, com revisão por diferentes técnicas e observadores, e da captura híbrida II (CH II) no diagnóstico da neoplasia intra-epitelial cervical (NIC) de alto grau, foram incluídas 105 mulheres atendidas entre agosto de 2000 e junho de 2001 por atipias pré-neoplásicas na CO. Todas foram submetidas à coleta de...
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