Encontrados 4 documentos, a visualizar página 1 de 1
Early modification of sickle cell disease clinical course by UDP-glucuronosyltr...
Martins, R; Morais, A; Dias, A; Soares, I; Rolão, C; Ducla-Soares, J; Braga, L; Seixas, T; Nunes, B; Olim, G; Romão, L; Lavinha, J; Faustino, PElevated erythrocyte destruction in sickle cell disease (SCD) results in chronic hyperbilirubinaemia and, in a subset of patients, cholelithiasis occurs. We investigated whether the (TA)n promoter polymorphism in the UDP-glucuronosyltransferase 1A1 gene (UGT1A1) may modify bilirubin metabolism, influencing bilirubinaemia, predisposition to cholelithiasis and subsequent cholecystectomy, in a group of 153 young S...
Orthostatic tachycardia syndromes.
Ducla-Soares, J L; Serviço de Medicina 3, Hospital de Santa Maria, Lisboa.Orthostatic tachycardia may be due to several physiologic abnormalities. Normal regulation of cardiac frequency in relation to postural changes is described; main causes of orthostatic tachycardia are described, in particular hypovolemia, beta-adrenergic hypersensitivity and segmental autonomic neuropathy. The current therapeutic attitudes are discussed. ; Orthostatic tachycardia may be due to several physiolo...
Atypical radiologic features of pulmonary tuberculosis. Nodular images in strin...
Azevedo, P; Serviço de Pneumologia e de Medicina 3. Hospital de Santa Maria/Faculdade de Medicina de Lisboa.; Ducla-Soares, J LChest radiographs are an important tool for the diagnosis and follow-up. Yet the radiographic findings can vary significantly, ranging from the so-called usual to unusual patterns. In this paper the authors report three cases of pulmonary tuberculosis in which the chest radiographs showed a nodular, pseudo-tumoral pattern. Based on literature and on their own experience, the authors discuss the frequency of thi...
Pure autonomic failure.
Ducla-Soares, J L; Serviço de Medicina III, Hospital de Santa Maria, Lisboa.; Guerreiro, A S; Póvoa, P; Alvares, E; Guerreiro, L; Carrilho, F; Santos, MWe present the case of a 64-year-old woman who, in the past 5 years, complained of constipation/diarrhea, hyposudoresis, xerostomia and xerophthalmia, dysuria and orthostatic hypotension. Cardiovascular reflexes analysis revealed sympathetic and parasympathetic failure. Norepinephrine was markedly reduced, both lying and after tilt. Norepinephrine infusion determined a significant rise in blood pressure, allowi...
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