Encontrados 6 documentos, a visualizar página 1 de 1
Starch-based microparticles as carriers for the delivery of platelet-derived gr...
Silva, G. A.; Coutinho, O. P.; Ducheyne, P.; Shapiro, I. M.; Reis, R. L.We have previously shown that starch-based microparticles are bioactive [1], serve as substrates for the culture of osteoblast-like cells [2], and are suitable for controlled release applications [3]. In this way, we postulate that if we combine these different properties we could generate hybrid constructs with enhanced properties. Hence, we describe herein the encapsulation and release of Platelet-Derived Gro...
Materials in particulate form for tissue engineering. 1 Basic concepts
Silva, G. A.; Ducheyne, P.; Reis, R. L.For biomedical applications, materials small in size are growing in importance. In an era where ‘nano’ is the new trend, micro- and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro- and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarl...
Materials in particulate form for tissue engineering. 2 Applications in bone
Silva, G. A.; Coutinho, O. P.; Ducheyne, P.; Reis, R. L.Materials in particulate form have been the subjects of intensive research in view of their use as drug delivery systems. While within this application there are still issues to be addressed, these systems are now being regarded as having a great potential for tissue engineering applications. Bone repair is a very demanding task, due to the specific characteristics of skeletal tissues, and the design of scaffol...
Starch-based microparticles as vehicles for the delivery of active platelet-der...
Silva, G. A.; Coutinho, O. P.; Ducheyne, P.; Shapiro, I. M.; Reis, R. L.In a previous work, we described the use of starch-based microparticles as vehicles for the controlled release of corticosteroids. The goal of the present work is to evaluate the potential of these microparticles to incorporate and release platelet-derived growth factor (PDGF). The loading efficiency and release profile were evaluated, and PDGF was incorporated into and released from the matrix of starch-based ...
The effect of starch and starch-bioactive glass composite microparticles on the...
Silva, G. A.; Coutinho, O. P.; Ducheyne, P.; Shapiro, I. M.; Reis, R. L.There is a clear need for the development of microparticles that can be used simultaneously as carriers of stem/progenitor cells and as release systems for bioactive agents, such as growth factors or differentiation agents. In addition, when thinking on bone-tissueengineering applications, it would be very useful if these microparticles are biodegradable and could be made to be bioactive. Microparticles with al...
Synthesis and evaluation of novel bioactive composite starch/bioactive glass mi...
Silva, G. A.; Costa, F. J.; Coutinho, O. P.; Radin, S.; Ducheyne, P.; Reis, R. L.The aim of the development of composite materials is to combine the most desired properties of two or more materials. In this work, the biodegradable character, good controlled-release properties, and natural origin of starch-based biomaterials are combined with the bioactive and bone-bonding properties of bioactive glass (BG). Novel, bioactive composite starch-BG microparticles were synthesized starting from a...
| Financiadores do RCAAP | |||||||
|
|
|
|
|
|
||