Suicide gene therapy is based on the introduction into tumor cells of a viral or a bacterial gene, which allows the conversion of a non-toxic compound into a lethal drug. Although suicide gene therapy has been successfully used in a large number of in vitro and in vivo studies, its application to cancer patients has not reached the desirable clinical significance. However, recent reports on pre-clinical cancer ...
Projeto de Mestrado em Educação e Tecnologia em Matemática apresentada à ESECS - Escola Superior de Educação e Ciências Sociais do Instituto Politécnico de Leiria. ; O presente trabalho consiste na construção de módulos interativos de Funções Reais de Variável Real para a disciplina de Matemática A do 11.º Ano de escolaridade que pode contribuir para diversificar práticas letivas, motivar alunos e criar condiç...
Sabe-se que a deficiência de iodo no ambiente está relacionada com disfunções da glândula tiróide provocando o bócio. Assim, esta dissertação reside na necessidade de medir, através de um método analítico adequado, o iodo na água destinada ao consumo humano, e relacionar o seu teor, que se supõe ser baixo, com as doenças associadas à IDD. Para atingir este objectivo procedeu-se à validação do método, “leuco cri...
Copyright © 2009 Universita degli Studi di Firenze. ; This study was carried out in a strawberry (Fragaria × ananassa Duch.) field located in Ribatejo, Portugal, and aims to describe the qualitative component of the visits for three strawberry floral visitors, attaining the best results in a previous work. The main objectives were: (1) to assess the pollination rate (PR) resulting from a single visit of Apis m...
Cell penetrating peptides have been successfully used to mediate the intracellular delivery of a wide variety of molecules of pharmacological interest. The main aim of the present work was to evaluate the potential of the S413-PV cell penetrating peptide to mediate the intracellular delivery of plasmid DNA, aiming at its use in gene therapy applications. The S413-PV cell penetrating peptide is a chimeric peptid...
In this study, we address the theory behind the ecological functions provided by biodiversity and ecological infra-structures, as well as their role in enhancing the performance of natural enemies, in agrarian ecosystems. This study focuses on the processing tomato agrarian ecosystem. In this crop, the key pest is the tomato fruitworm, which is followed by a complex of natural enemies, essentially parasitoids. ...
Copyright © 2005 Elsevier Inc. All rights reserved. ; Minute egg parasitoids of the genus Trichogramma (Hymenoptera; Trichogrammatidae) are promising candidates for biological control of lepidopteran pests in tomato in Portugal. This certainly applies to native Trichogramma strains that have thelytokous reproduction, i.e., produce only daughters. In Trichogramma wasps, thelytoky is mostly induced by the intrac...
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