Breast cancer is the most common cause of cancer mortality among women worldwide. Among the several factors associated with breast cancer development, angiogenesis plays an essential role and has currently emerged as a potential diag¬nostic, prognostic and therapeutic target. Protease-activated receptor 1 (PAR1) and fibroblast growth factor receptor 1 (FGFR1) have important activities in tumor angiogenesis and ...
Tese de doutoramento na área de ciências da saúde, ramo de ciências biológicas e biomédicas ; Angiogenesis, the development of new blood vessels from the existing vasculature, is controlled by different signaling pathways, where diverse cytokines, chemokines and growth factors play important roles. Angiogenesis and blood coagulation are key events of vascular biology. Serine protease, thrombin, which plays a c...
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